2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture

Julius Adam V. Lopez; Toshihiko Nogawa; Kazuko Yoshida; Yushi Futamura; Hiroyuki Osada

doi:10.1093/bbb/zbab192

2-Methylthio-N⁷-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture

Julius Adam V. Lopez, Toshihiko Nogawa, Kazuko Yoshida, Yushi Futamura, Hiroyuki Osada^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5′-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 μm and had no effect on the growth of Arabidopsis at 2 μm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound.

Original language	English
Pages (from-to)	31-36
Number of pages	6
Journal	Bioscience, Biotechnology and Biochemistry
Volume	86
Issue number	1
DOIs	https://doi.org/10.1093/bbb/zbab192
Publication status	Published - 2022 Jan 1
Externally published	Yes

Keywords

Plasmodium falciparum
Streptomyces
antimalaria
zeatin

ASJC Scopus subject areas

Medicine(all)

Access to Document

10.1093/bbb/zbab192

Cite this

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title = "2-Methylthio-N7-methyl-cis-zeatin, a new antimalarial natural product isolated from a Streptomyces culture",

abstract = "2-Methylthio-N7-methyl-cis-zeatin (1) was isolated from the culture broth of Streptomyces sp. 80H647 along with 2 known purine derivatives, 5′-methylthioinosine (2) and AT-265 (dealanylascamycin, 3). The structure elucidation of compound 1 was accomplished by high-resolution mass spectrometry (HRMS) and nuclear magnetic resonance (NMR) analyses. It inhibited the growth of Plasmodium falciparum 3D7 with a GI50 of 2.4 μm and had no effect on the growth of Arabidopsis at 2 μm. This is the first report of an N7-methylated zeatin-type natural product from Streptomyces and as an antimalarial compound.",

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AU - Futamura, Yushi

AU - Osada, Hiroyuki

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