A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties

Toshinori Fujie; Sho Furutate; Daisuke Niwa; Shinji Takeoka

doi:10.1039/c0sm00527d

A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties

Toshinori Fujie, Sho Furutate, Daisuke Niwa, Shinji Takeoka^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechano-biological approach for the development of tissue-engineering scaffolds.

Original language	English
Pages (from-to)	4672-4676
Number of pages	5
Journal	Soft Matter
Volume	6
Issue number	19
DOIs	https://doi.org/10.1039/c0sm00527d
Publication status	Published - 2010 Oct 7

ASJC Scopus subject areas

Chemistry(all)
Condensed Matter Physics

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abstract = "We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechano-biological approach for the development of tissue-engineering scaffolds.",

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AU - Fujie, Toshinori

AU - Furutate, Sho

AU - Niwa, Daisuke

AU - Takeoka, Shinji

PY - 2010/10/7

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N2 - We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechano-biological approach for the development of tissue-engineering scaffolds.

AB - We report an artificially fabricated extracellular matrix (ECM)-like nanostructure, which utilizes self-assembly of collagen and hyaluronic acid in a quasi two-dimensional space of tens-of-nm thickness, displaying different cellular adhesive characteristics depending on the structural properties between the fibril and non-fibril elements. This nano-fibrous assembly will facilitate a mechano-biological approach for the development of tissue-engineering scaffolds.

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A nano-fibrous assembly of collagen-hyaluronic acid for controlling cell-adhesive properties

Abstract

ASJC Scopus subject areas

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