A new approach to control central deafferentation pain: Spinal intrathecal baclofen

Takaomi Taira*, Hirotsune Kawamura, Tatsuya Tanikawa, Hiroshi Iseki, Hiroko Kawabatake, Kintomo Takakura

*Corresponding author for this work

    Research output: Contribution to journalArticlepeer-review

    63 Citations (Scopus)


    Baclofen, an agonist of the γ-aminobutyric acid (GABA) receptor, has antinociceptive effects, and its intrathecal administration reduces allodynic responses in animal models of neurogenic central pain. Such experimental studies lead to the hypothesis that neurogenic pain may be induced in part by functional abnormalities in spinal GABAergic systems. However, whether a GABAergic system is actually involved in human central pain is unknown. The authors investigated the effect of an intrathecal bolus injection of baclofen in 14 patients with central pain due to a stroke or spinal cord injury. Nine reported substantial pain relief they had never experienced previously. The effect appeared 1–2 h after the injection and persisted for 10–24 h. Allodynia and hyperalgesia, if present, were relieved as well. Pinprick and light touch sensations did not change in nonaffected regions. The results indicate that dysfunction of spinal GABAergic systems plays a role in the clinical expression of central pain. In clinical situations, continuous intrathecal infusion of baclofen seems feasible for relief of central pain.

    Original languageEnglish
    Pages (from-to)101-105
    Number of pages5
    JournalStereotactic and Functional Neurosurgery
    Issue number1-4
    Publication statusPublished - 1995


    • Baclofen
    • Central pain
    • GABA
    • Pain relie

    ASJC Scopus subject areas

    • Surgery
    • Clinical Neurology


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