A study of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima; Shin Ichi Takeda; Fumihito Mishima; Yasuhiko Tabata; Masaya Yamamoto; Jun Ichiro Joh; Hiroshi Iseki; Yoshihiro Muragaki; Akira Sasaki; Jun Kubota; Norihide Saho

doi:10.1109/TASC.2008.921967

A study of magnetic drug delivery system using bulk high temperature superconducting magnet

Shigehiro Nishijima^*, Shin Ichi Takeda, Fumihito Mishima, Yasuhiko Tabata, Masaya Yamamoto, Jun Ichiro Joh, Hiroshi Iseki, Yoshihiro Muragaki, Akira Sasaki, Jun Kubota, Norihide Saho

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

Original language	English
Article number	4517321
Pages (from-to)	874-877
Number of pages	4
Journal	IEEE Transactions on Applied Superconductivity
Volume	18
Issue number	2
DOIs	https://doi.org/10.1109/TASC.2008.921967
Publication status	Published - 2008 Jun
Externally published	Yes

Keywords

Bulk high temperature superconductor
Magnetic drug delivery system
Magnetic seeded drug
Nano-sized particle
Navigation of drag

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
Condensed Matter Physics
Electrical and Electronic Engineering

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1109/TASC.2008.921967

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title = "A study of magnetic drug delivery system using bulk high temperature superconducting magnet",

abstract = "A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.",

keywords = "Bulk high temperature superconductor, Magnetic drug delivery system, Magnetic seeded drug, Nano-sized particle, Navigation of drag",

author = "Shigehiro Nishijima and Takeda, {Shin Ichi} and Fumihito Mishima and Yasuhiko Tabata and Masaya Yamamoto and Joh, {Jun Ichiro} and Hiroshi Iseki and Yoshihiro Muragaki and Akira Sasaki and Jun Kubota and Norihide Saho",

note = "Funding Information: Manuscript received August 25, 2007. This work was supported in part by NEDO under R/D Project on Next-Generation DDS Treatment Systems for Malignant Tumors, R/D on Next-Generation DDS Treatment Systems for Deep Therapy.",

year = "2008",

month = jun,

doi = "10.1109/TASC.2008.921967",

language = "English",

volume = "18",

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AU - Nishijima, Shigehiro

AU - Takeda, Shin Ichi

AU - Mishima, Fumihito

AU - Tabata, Yasuhiko

AU - Yamamoto, Masaya

AU - Joh, Jun Ichiro

AU - Iseki, Hiroshi

AU - Muragaki, Yoshihiro

AU - Sasaki, Akira

AU - Kubota, Jun

AU - Saho, Norihide

N1 - Funding Information: Manuscript received August 25, 2007. This work was supported in part by NEDO under R/D Project on Next-Generation DDS Treatment Systems for Malignant Tumors, R/D on Next-Generation DDS Treatment Systems for Deep Therapy.

PY - 2008/6

Y1 - 2008/6

N2 - A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

AB - A magnetic drug delivery system (MDDS) has been studied to navigate and/or accumulate the magnetic seeded drug at a local diseased part in the human body. The bulk high temperature superconductors (HTS) are employed to control the drug because they would produce the required magnetic fields for MDDS. The trajectory of the ferromagnetic particles in the blood vessel was calculated and the possibility of the navigation of the drug is discussed. In the experiment the HTS (GdBaCuO) which produces the magnetic field of 4.5 T at the surface, was located 25 mm apart from the Y-shaped blood vessel. The drug navigation probability to the desired direction was confirmed to be higher than 80%. A rat experiment was also performed successfully using a permanent magnet. The possible MDDS system will be discussed.

KW - Bulk high temperature superconductor

KW - Magnetic drug delivery system

KW - Magnetic seeded drug

KW - Nano-sized particle

KW - Navigation of drag

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A study of magnetic drug delivery system using bulk high temperature superconducting magnet

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Keywords

ASJC Scopus subject areas

UN SDGs

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