A tissue-silicone integrated simulator for right ventricular pulsatile circulation with severe functional tricuspid regurgitation

Jumpei Takada, Hayato Morimura, Kohei Hamada, Yusei Okamoto, Shiho Mineta, Yusuke Tsuboko, Kaoru Hattori, Kiyotaka Iwasaki*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

There is a great demand for development of a functional tricuspid regurgitation (FTR) model for accelerating development and preclinical study of tricuspid interventional repair devices. This study aimed to develop a severe FTR model by creating a tissue-silicone integrated right ventricular pulsatile circulatory simulator. The simulator incorporates the porcine tricuspid annulus, valve leaflets, chordae tendineae, papillary muscles, and right ventricular wall as one continuous piece of tissue, thereby preserving essential anatomical relationships of the tricuspid valve (TV) complex. We dilated the TV annulus with collagenolytic enzymes under applying stepwise dilation, and successfully achieved a severe FTR model with a regurgitant volume of 45 ± 9 mL/beat and a flow jet area of 15.8 ± 2.3 cm2 (n = 6). Compared to a normal model, the severe FTR model exhibited a larger annular circumference (133.1 ± 8.2 mm vs. 115.7 ± 5.5 mm; p = 0.009) and lower coaptation height (6.6 ± 1.0 mm vs. 17.7 ± 1.3 mm; p = 0.003). Following the De-Vega annular augmentation procedure to the severe FTR model, a significant reduction in regurgitant volume and flow jet area were observed. This severe FTR model may open new avenues for the development and evaluation of transcatheter TV devices.

Original languageEnglish
Article number5120
JournalScientific reports
Volume14
Issue number1
DOIs
Publication statusPublished - 2024 Dec

ASJC Scopus subject areas

  • General

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