TY - JOUR
T1 - Accelerated Wound Healing on Skin by Electrical Stimulation with a Bioelectric Plaster
AU - Kai, Hiroyuki
AU - Yamauchi, Takeshi
AU - Ogawa, Yudai
AU - Tsubota, Ayaka
AU - Magome, Takahiro
AU - Miyake, Takeo
AU - Yamasaki, Kenshi
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
The authors are grateful to Masanori Fujisawa, Airi Anzai, and Yasuyuki Omura for their technical assistance in the development of an eight-channel battery logger for 12 h stability measurement of bioelectric plasters. All animal experiments were approved by the Animal Care and Experimentation Committee of Tohoku University Graduate School of Medicine. This work was supported in part by Center of Innovation Program (COI-Stream) and Creation of Innovation Centers for Advanced Interdisciplinary Research Area Program from Japan Science and Technology Agency (JST), Regional Innovation Strategy Support Program “Knowledge-based Medical Device Cluster/Miyagi Area,” Grand-in-Aid for Scientific Research A (25246016), and Challenging Exploratory Research (K15K13315) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
Publisher Copyright:
© 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim
PY - 2017/11/22
Y1 - 2017/11/22
N2 - Wound healing on skin involves cell migration and proliferation in response to endogenous electric current. External electrical stimulation by electrical equipment is used to promote these biological processes for the treatment of chronic wounds and ulcers. Miniaturization of the electrical stimulation device for wound healing on skin will make this technology more widely available. Using flexible enzymatic electrodes and stretchable hydrogel, a stretchable bioelectric plaster is fabricated with a built-in enzymatic biofuel cell (EBFC) that fits to skin and generates ionic current along the surface of the skin by enzymatic electrochemical reactions for more than 12 h. To investigate the efficacy of the fabricated bioelectric plaster, an artificial wound is made on the back skin of a live mouse and the wound healing is observed for 7 d in the presence and absence of the ionic current of the bioelectric plaster. The time course of the wound size as well as the hematoxylin and eosin staining of the skin section reveals that the ionic current of the plaster leads to faster and smoother wound healing. The present work demonstrates a proof of concept for the electrical manipulation of biological functions by EBFCs.
AB - Wound healing on skin involves cell migration and proliferation in response to endogenous electric current. External electrical stimulation by electrical equipment is used to promote these biological processes for the treatment of chronic wounds and ulcers. Miniaturization of the electrical stimulation device for wound healing on skin will make this technology more widely available. Using flexible enzymatic electrodes and stretchable hydrogel, a stretchable bioelectric plaster is fabricated with a built-in enzymatic biofuel cell (EBFC) that fits to skin and generates ionic current along the surface of the skin by enzymatic electrochemical reactions for more than 12 h. To investigate the efficacy of the fabricated bioelectric plaster, an artificial wound is made on the back skin of a live mouse and the wound healing is observed for 7 d in the presence and absence of the ionic current of the bioelectric plaster. The time course of the wound size as well as the hematoxylin and eosin staining of the skin section reveals that the ionic current of the plaster leads to faster and smoother wound healing. The present work demonstrates a proof of concept for the electrical manipulation of biological functions by EBFCs.
KW - electrical stimulation
KW - enzymatic biofuel cells
KW - wearable devices
KW - wound healing
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U2 - 10.1002/adhm.201700465
DO - 10.1002/adhm.201700465
M3 - Article
C2 - 28929631
AN - SCOPUS:85030102261
SN - 2192-2640
VL - 6
JO - Advanced healthcare materials
JF - Advanced healthcare materials
IS - 22
M1 - 1700465
ER -