Actinomycins produced by streptomyces lichenis lcr6-01t and its antibacterial activity

Pawina Kanchanasin, Patcharin Saeng-In, Takuji Nakashima, Hirotaka Matsuo, Yōko Takahashi, Somboon Tanasupawat*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


A new actinomycete species, Streptomyces lichenis LCR6-01T was isolated from lichen collected in Chiang Rai province, Thailand. On the course of screening for antimicrobial activity, the culture broth of strain LCR6-01T exhibited antibacterial activity against Bacillus subtilis ATCC 6633, Kocuria rhizophila ATCC 9341, Staphylococcus aureus ATCC 25923 and Escherichia coli ATCC 25922 (inhibition zone 14.7 ± 0.6-23.0 ± 0.9 mm). The culture extracts analyzed by liquid chromatographyelectrospray ionization-mass spectrometry (LC-ESI-MS) and the physicochemical properties of secondary metabolites were searched in database. The antibacterial agents were detected as actinomycins which contained 3 analogs of Au7a, D, and D 43β.

Original languageEnglish
Pages (from-to)864-871
Number of pages8
JournalChiang Mai Journal of Science
Issue number5
Publication statusPublished - 2020 Sept
Externally publishedYes


  • Actinomycin
  • Antimicrobial activity
  • Mass spectrometry
  • Streptomyces lichenis

ASJC Scopus subject areas

  • General Chemistry
  • General Mathematics
  • General Materials Science
  • General Biochemistry,Genetics and Molecular Biology
  • General Physics and Astronomy


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