Activity of some atypical antidepressants on five models of muricide in rat

I. M.H. Al-Khatib, M. Fujiwara, S. Shibata, S. Ueki

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1 Citation (Scopus)


We examined the effects of atypical antidepressants; nomifensine (NOM), zimelidine (ZIM) and mianserin (MIAN) on muricide induced by olfactory bulbectomy (OB), lesions of raphe nuclei (Raphe) and nucleus accumbens (ACC), and Δ9-tetrahydrocannabinol (THC) administration, in comparison with that of (IMP). NOM selectively suppressed muricide induced by ACC lesion and THC administration; ZIM and IMP showed higher selectivity in suppressing muricide in all models studied while MIAN only in ACC lesioned rats. These results besides revealing that muricide of ACC rats was most prominently suppressed by antidepressants, also indicated the possible relationship between the causal factors of muricide and the mechanisms of action of some of the drugs used.

Original languageEnglish
Pages (from-to)79-85
Number of pages7
JournalAsia Pacific Journal of Pharmacology
Issue number2
Publication statusPublished - 1986 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Pharmacology


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