ACTN3 polymorphism affects thigh muscle area

H. Zempo, K. Tanabe, H. Murakami, M. Iemitsu, S. Maeda, S. Kuno*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

53 Citations (Scopus)


Muscle mass is an important factor influencing the activity of daily living in older adults. We aimed to investigate whether -actinin-3 (ACTN3) gene R577X polymorphism affects muscle mass in older Japanese women. A total of 109 women (mean±SD, 64.1±6.0 years) were genotyped for the R/X variant of ACTN3. Mid-thigh muscle cross-sectional area (CSA) was assessed using MRI and compared using analysis of covariance models adjusted for body weight. In addition, physical activity and protein intake were measured as the living environmental factors affecting muscle mass. The ACTN3 R577X genotype distributions of the subjects were 19, 63 and 27 for the RR, RX, and XX genotypes, respectively. No differences in physical activity and protein intake were observed among the genotypes. The XX genotype showed lower thigh muscle CSA compared with RR&RX genotype (mean±SEM; XX: 69.1±1.8cm 2, RR&RX: 73.6±1.1cm2; p<0.05). The results of the present study suggest that ACTN3 R577X polymorphism influences muscle mass in older Japanese women.

Original languageEnglish
Pages (from-to)138-142
Number of pages5
JournalInternational journal of sports medicine
Issue number2
Publication statusPublished - 2010
Externally publishedYes


  • Alpha-actinin-3
  • Gene
  • Leg
  • Skeletal muscle

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation


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