TY - JOUR
T1 - ACTN3 R577X genotype and athletic performance in a large cohort of Japanese athletes
AU - Kikuchi, Naoki
AU - Miyamoto-Mikami, Eri
AU - Murakami, Haruka
AU - Nakamura, Tomohiro
AU - Min, Seok Ki
AU - Mizuno, Masuhiko
AU - Naito, Hisashi
AU - Miyachi, Motohiko
AU - Nakazato, Koichi
AU - Fuku, Noriyuki
N1 - Funding Information:
This work was supported by a Grant-in-Aid for Research Activity Start-up (26882041 to N. K.), Grants-in-Aid for Challenging Exploratory Research (24650414 to N. F.), Grants-in-Aid for Scientific Research (C) (23500788 to K. N.) from the Ministry of Education, Culture, Sports, Science, and Technology, and by a Grant-in-Aid for Scientific Research from the Ministry of Health, Labor, and Welfare of Japan (to M. Miyachi).
Publisher Copyright:
© 2015 European College of Sport Science.
PY - 2016/8/17
Y1 - 2016/8/17
N2 - Abstract: Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16–2.18; P =.003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P =.001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P =.030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.
AB - Abstract: Aim: Recent meta-analyses of the literature confirmed the association between the RR+RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athletic status in Europeans but not in Asians and Africans, while the association between the R577X genotype and elite endurance athlete status is less convincing. The aim of the present study was to investigate the association between the ACTN3 R577X genotype and elite athlete status in a large Asian (Japanese) cohort of track and field athletes. Methods: One-thousand fifty-seven Japanese track and field athletes (627 sprint/power athletes and 430 endurance athletes) and 810 Japanese controls were genotyped for the ACTN3 R577X polymorphism (rs1815739) by using the TaqMan® SNP Genotyping Assay. Results: Elite sprint/power athletes had a higher frequency of the RR+RX genotype than the controls (OR: 1.59, 95% CI: 1.16–2.18; P =.003). A significant linear correlation was found between the RR + RX genotype and athlete status (i.e. regional < national < international) in sprint/power athletes (regional: 71%, national: 81%, international: 84%; P =.001 for trend) and long-distance runners (regional: 65%, national: 72%, international: 82%; P =.030 for trend). Conclusions: The data obtained for this large Asian (Japanese) cohort of track and field athletes served to confirm the association between the RR + RX genotype of the ACTN3 R577X polymorphism and elite sprint/power athlete status and also the association between the ACTN3 RR + RX genotype and long-distance running athletic status.
KW - Asian
KW - Sprint/power
KW - endurance
KW - physical performance
KW - polymorphism
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U2 - 10.1080/17461391.2015.1071879
DO - 10.1080/17461391.2015.1071879
M3 - Article
C2 - 26324221
AN - SCOPUS:84940514288
SN - 1746-1391
VL - 16
SP - 694
EP - 701
JO - European Journal of Sport Science
JF - European Journal of Sport Science
IS - 6
ER -