TY - JOUR
T1 - Acute effects of transdermal administration of jojoba oil on lipid metabolism in mice
AU - Matsumoto, Yutaka
AU - Ma, Sihui
AU - Tominaga, Takaki
AU - Yokoyama, Keiko
AU - Kitatani, Kanae
AU - Horikawa, Kazumasa
AU - Suzuki, Katsuhiko
N1 - Funding Information:
Funding: Grants-in-aid of Scientific Research (JSPS KAKENHI Grant Number: 16K15878) from 2016–2017, by the Japan Ministry of Education, Culture, Sports, Science and Technology (to author Y.M.) supported this work. Grants from Waseda University and Tokai University also supported this work. None of these funding sources had any role in the study’s design, data collection, analyses, decision to publish, or manuscript preparation.
Publisher Copyright:
© 2019 by the authors.
PY - 2019/9
Y1 - 2019/9
N2 - Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 µL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.
AB - Background and objectives: Aroma therapy is a complementary therapy using essential oils diluted with carrier oils. Jojoba oils have been widely used as carrier oils. However, limited information is available regarding their effects on blood biochemical parameters. This study aimed to investigate the effect of transdermal administration of jojoba oil on blood biochemical parameters in mice. Materials and Methods: Eight-week-old male hairless mice were randomly divided into naïve control and treatment groups. In the treatment group, mice were topically administered 4 µL of jojoba oil, per gram of body weight, on the dorsa 30 min before euthanasia. Thereafter, serum biochemical parameters were assayed, and gene expression was analyzed in various tissues via a real-time polymerase chain reaction. Results: Serum non-esterified fatty acid (NEFA) levels increased significantly 30 min after topical application of jojoba oil (p < 0.05). Atgl was significantly upregulated in the liver (p < 0.05), and Atgl upregulation in the liver was positively correlated with serum NEFA levels (r = 0.592, p < 0.05). Furthermore, a trend of decreasing fatty acid trafficking-related gene (FABPpm, FATP-1, FATP-3, and FATP-4) expression in the skin after topical application of jojoba oil (p = 0.067, 0.074, 0.076, and 0.082, respectively) was observed. Conclusions: Serum NEFA levels were elevated 30 min after transdermal administration of jojoba oil. The mechanisms of elevated serum NEFA levels might be related to both enhanced lipolysis in the liver and reduced fatty acid trafficking in the skin.
KW - Aromatherapy
KW - Fatty acid
KW - Jojoba oil
KW - Lipid metabolism
KW - Non-esterified fatty acids (NEFA)
KW - Transdermal absorption
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U2 - 10.3390/medicina55090594
DO - 10.3390/medicina55090594
M3 - Article
C2 - 31540183
AN - SCOPUS:85072527890
SN - 1010-660X
VL - 55
JO - Medicina (Lithuania)
JF - Medicina (Lithuania)
IS - 9
M1 - 594
ER -