TY - JOUR
T1 - Acute hemodynamic and glycolytic metabolic changes of liposome embedded heme (L/H) in the hemorrhagic dog
AU - Watanabe, Masazumi
AU - Kobayashi, Koichi
AU - Ishihara, Tsuneo
AU - Nishide, Hiroyuki
AU - Tsuchida, Eisyun
PY - 1991
Y1 - 1991
N2 - The effects of intravenous transfusion of liposome-embedded heme (L/H) on acute hemodynamic and glycolytic metabolic changes were evaluated in hemorrhagic dogs. Under controlled ventilation, 30 ml/ kg of blood was drawn. Blood pressure, histamine release, PAP, PCWP, CVP and CO were measured. After 30 minutes, 30 ml/kg of L/H solution (group A) or normal saline solution (group B) was intravenously injected, and no transfusion was peformed in group C. The above parameters and serum lactate and pyruvate concentration were measured. The data obtained show that hemorrhagic hypotension and anaerobic glycolysis were reversed by L/H injection.
AB - The effects of intravenous transfusion of liposome-embedded heme (L/H) on acute hemodynamic and glycolytic metabolic changes were evaluated in hemorrhagic dogs. Under controlled ventilation, 30 ml/ kg of blood was drawn. Blood pressure, histamine release, PAP, PCWP, CVP and CO were measured. After 30 minutes, 30 ml/kg of L/H solution (group A) or normal saline solution (group B) was intravenously injected, and no transfusion was peformed in group C. The above parameters and serum lactate and pyruvate concentration were measured. The data obtained show that hemorrhagic hypotension and anaerobic glycolysis were reversed by L/H injection.
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M3 - Article
AN - SCOPUS:0026392921
SN - 2169-1401
VL - 19
SP - 502
JO - Artificial Cells, Nanomedicine and Biotechnology
JF - Artificial Cells, Nanomedicine and Biotechnology
IS - 2
ER -