Aerobic amide bond formation with N-hydroxysuccinimide

Haoyi Yao; Kana Yamamoto

doi:10.1002/asia.201200017

Aerobic amide bond formation with N-hydroxysuccinimide

Haoyi Yao, Kana Yamamoto^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

38 Citations (Scopus)

Abstract

Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) ₂ and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

Original language	English
Pages (from-to)	1542-1545
Number of pages	4
Journal	Chemistry - An Asian Journal
Volume	7
Issue number	7
DOIs	https://doi.org/10.1002/asia.201200017
Publication status	Published - 2012 Jun 1
Externally published	Yes

Keywords

amides
oxidation
oxygen
peptide coupling
synthetic methods

ASJC Scopus subject areas

Biochemistry
Organic Chemistry

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10.1002/asia.201200017

Cite this

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abstract = "Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.",

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author = "Haoyi Yao and Kana Yamamoto",

year = "2012",

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AU - Yamamoto, Kana

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AB - Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

KW - amides

KW - oxidation

KW - oxygen

KW - peptide coupling

KW - synthetic methods

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ER -

Aerobic amide bond formation with N-hydroxysuccinimide

Abstract

Keywords

ASJC Scopus subject areas

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