Aerobic amide bond formation with N-hydroxysuccinimide

Haoyi Yao, Kana Yamamoto*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Breathe easy: Molecular oxygen is one of the most abundant, atom-efficient, and economical oxidants. An aerobic oxidative amide formation from aldehydes and amines is reported. The method uses a catalytic amount of Co(OAc) 2 and N-hydroxysuccinimide as reaction promoters. It is applicable to chiral substrates without loss of their optical purity.

Original languageEnglish
Pages (from-to)1542-1545
Number of pages4
JournalChemistry - An Asian Journal
Issue number7
Publication statusPublished - 2012 Jun 1
Externally publishedYes


  • amides
  • oxidation
  • oxygen
  • peptide coupling
  • synthetic methods

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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