Age-related changes in thrombopoietin in children: Reference interval for serum thrombopoietin levels

Akera Ishiguro*, Tatsutoshi Nakahata, Kousaku Matsubara, Yasuhide Hayashi, Takashi Kato, Yoko Suzuki, Toshikazu Shimbo

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

63 Citations (Scopus)


We studied thrombopoietin (TPO, Mpl ligand) values using a sensitive ELISA in 254 serum samples obtained from disease-free children and adult volunteers. TPO was detected in all samples, and its values ranged widely from 0.25 to 9.18 fmol/ml. When analysed by dividing the subjects into 11 age groups, the mean TPO levels from birth to 1 month of age were increased (3.73-5.92 fmol/ml). The highest values were found 2 d after birth; TPO levels then gradually decreased to adult levels (0.83 fmol/ml). The relationship between TPO values and platelet counts was not significant in all subjects (r=0.27) or in children alone (r=0.12). In children >1 month of age a 95% reference interval for serum TPO values was determined from 0.58 to 3.27 fmol/ml. A significant correlation was found between TPO values in serum and plasma; serum TPO values = -0.257 + 4.039 x plasma TPO values (r=0.951, P<0.001, n=22). This study is the first to report age-dependent changes in blood TPO levels throughout child development. Serum TPO values were significantly high up to 1 month of age and were correlated with plasma TPO levels.

Original languageEnglish
Pages (from-to)884-888
Number of pages5
JournalBritish Journal of Haematology
Issue number4
Publication statusPublished - 1999
Externally publishedYes


  • Children
  • Cord blood
  • Plasma
  • Serum
  • Thrombopoietin

ASJC Scopus subject areas

  • Hematology


Dive into the research topics of 'Age-related changes in thrombopoietin in children: Reference interval for serum thrombopoietin levels'. Together they form a unique fingerprint.

Cite this