TY - JOUR
T1 - Ageing and free-living daily physical activity effects on salivary beta-defensin 2 secretion
AU - Shimizu, Kazuhiro
AU - Hanaoka, Yukichi
AU - Akama, Takao
AU - Kono, Ichiro
N1 - Funding Information:
This work was supported by the Science Research from the Ministry of Education, Culture, Sports, Science and Technology of Japan [grant numbers 21700705 and 25750358 to Kazuhiro Shimizu].
Publisher Copyright:
© 2016 Informa UK Limited, trading as Taylor & Francis Group.
PY - 2017/4/3
Y1 - 2017/4/3
N2 - This study examined ageing and free-living daily physical activity effects on salivary human beta-defensin 2 (hBD2). A total of 168 healthy elderly and 26 healthy young volunteers underwent saliva sampling. Free-living step count, energy expenditure and activity durations at specific intensity levels (inactive, light, moderate and vigorous) were evaluated. The results show significantly lower salivary hBD2 secretion rates for elderly than for young participants (P < 0.05). Data from elderly participants were stratified by steps per day using quartiles (Q1–Q4) for distribution. Elderly in quartiles respectively showed step counts of 3145 ± 129 in Q1, 5294 ± 83 in Q2, 7001 ± 86 in Q3 and 10,236 ± 416 steps · day−1 in Q4. In elderly participants, significant differences were found in the mean step count, energy expenditure and activity duration with increasing pedometer-determined activity quartiles. hBD2 secretion rates were significantly higher for Q2, Q3 and Q4 than for Q1 (P < 0.05). Elderly participants in Q3 had the highest hBD2 secretion. In conclusion, these results suggest that moderate physical activity in daily living improves age-related impairment of oral immune function mediated by hBD2. For oral immune function enhancement and for prevention of upper respiratory tract infections in elderly people, we recommend accumulation of more than 7000 steps · day−1.
AB - This study examined ageing and free-living daily physical activity effects on salivary human beta-defensin 2 (hBD2). A total of 168 healthy elderly and 26 healthy young volunteers underwent saliva sampling. Free-living step count, energy expenditure and activity durations at specific intensity levels (inactive, light, moderate and vigorous) were evaluated. The results show significantly lower salivary hBD2 secretion rates for elderly than for young participants (P < 0.05). Data from elderly participants were stratified by steps per day using quartiles (Q1–Q4) for distribution. Elderly in quartiles respectively showed step counts of 3145 ± 129 in Q1, 5294 ± 83 in Q2, 7001 ± 86 in Q3 and 10,236 ± 416 steps · day−1 in Q4. In elderly participants, significant differences were found in the mean step count, energy expenditure and activity duration with increasing pedometer-determined activity quartiles. hBD2 secretion rates were significantly higher for Q2, Q3 and Q4 than for Q1 (P < 0.05). Elderly participants in Q3 had the highest hBD2 secretion. In conclusion, these results suggest that moderate physical activity in daily living improves age-related impairment of oral immune function mediated by hBD2. For oral immune function enhancement and for prevention of upper respiratory tract infections in elderly people, we recommend accumulation of more than 7000 steps · day−1.
KW - Antimicrobial peptide
KW - ageing
KW - defensin
KW - oral immune function
KW - physical activity
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U2 - 10.1080/02640414.2016.1182640
DO - 10.1080/02640414.2016.1182640
M3 - Article
C2 - 27237844
AN - SCOPUS:84971377576
SN - 0264-0414
VL - 35
SP - 617
EP - 623
JO - Journal of sports sciences
JF - Journal of sports sciences
IS - 7
ER -
