TY - JOUR
T1 - Aging impairs methamphetamine-induced free-running and anticipatory locomotor activity rhythms in rats
AU - Shibata, Shigenobu
AU - Minamoto, Yoshitsugu
AU - Ono, Michiko
AU - Watanabe, Shigenori
PY - 1994/5/19
Y1 - 1994/5/19
N2 - In the present experiment, under drinking of 0.01% methamphetamine (MA), young rats exhibited free-running locomotor rhythm ranging from 24.6 to 30.9 h period under light-dark cycle. In contrast, 24-month-old rats showed a low activity and did not exhibit MA-induced free-running rhythm. When MA was injected at a fixed time of day (14:00), young rats exhibited intense locomotor activity from 1-2 h before drug-injection time. This preinjection activity was still detected on the withdrawal day. In addition, intense locomotor activity was observed for 12:00-17:00, even on the withdrawal day (MA-associated anticipatory activity). Thus, MA-associated activity of the withdrawal day became an another good index for MA anticipatory activity rhythms whereas old rats did not exhibit this anticipatory activity. The present study suggests that aging strongly impairs the manifestation of MA-induced free-running and anticipatory activity rhythms in rats.
AB - In the present experiment, under drinking of 0.01% methamphetamine (MA), young rats exhibited free-running locomotor rhythm ranging from 24.6 to 30.9 h period under light-dark cycle. In contrast, 24-month-old rats showed a low activity and did not exhibit MA-induced free-running rhythm. When MA was injected at a fixed time of day (14:00), young rats exhibited intense locomotor activity from 1-2 h before drug-injection time. This preinjection activity was still detected on the withdrawal day. In addition, intense locomotor activity was observed for 12:00-17:00, even on the withdrawal day (MA-associated anticipatory activity). Thus, MA-associated activity of the withdrawal day became an another good index for MA anticipatory activity rhythms whereas old rats did not exhibit this anticipatory activity. The present study suggests that aging strongly impairs the manifestation of MA-induced free-running and anticipatory activity rhythms in rats.
KW - Aging
KW - Anticipation
KW - Circadian rhythm
KW - Learning
KW - Methamphetamine
KW - Non-photic entrainment
UR - http://www.scopus.com/inward/record.url?scp=0028343028&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0028343028&partnerID=8YFLogxK
U2 - 10.1016/0304-3940(94)90673-4
DO - 10.1016/0304-3940(94)90673-4
M3 - Article
C2 - 8084510
AN - SCOPUS:0028343028
SN - 0304-3940
VL - 172
SP - 107
EP - 110
JO - Neuroscience Letters
JF - Neuroscience Letters
IS - 1-2
ER -