TY - JOUR
T1 - AGTR2 and sprint/power performance
T2 - A case-control replication study for rs11091046 polymorphism in two ethnicities
AU - Yvert, Thomas P.
AU - Zempo, Hirofumi
AU - Gabdrakhmanova, Leysan J.
AU - Kikuchi, Naoki
AU - Miyamoto-Mikami, Eri
AU - Murakami, Haruka
AU - Naito, Hisashi
AU - Cieszczyk, Pawel
AU - Leznicka, Katarzyna
AU - Kostryukova, Elena S.
AU - Alexeev, Dmitry G.
AU - Egorova, Emiliya S.
AU - Maciejewska-Skrendo, Agnieszka
AU - Larin, Andrey K.
AU - Generozov, Edward V.
AU - Kulemin, Nickolay A.
AU - Ospanova, Elena A.
AU - Pavlenko, Alexander V.
AU - Sawczuk, Marek
AU - Zmijewski, Piotr
AU - Lulinska-Kuklik, Ewelina
AU - Govorun, Vadim M.
AU - Miyachi, Motohiko
AU - Ahmetov, Ildus I.
AU - Fuku, Noriyuki
N1 - Funding Information:
This work was supported in part by grants from the Grant-in-Aid for Scientific Research program of the Ministry of Education, Culture, Sports, Science and Technology of Japan (Grant No. 15H03081 to N.F.; DNA sample collection and genotyping of Japanese athletes and controls); by a grant-in-aid for scientific research from the Ministry of Health, Labor, and Welfare of Japan (to M.M.; DNA sample collection of controls) and by grants from the Russian Science Foundation (Grant No. 17-15-01436: “Comprehensive analysis of the contribution of genetic, epigenetic and environmental factors in the individual variability of the composition of human muscle fibers”; DNA sample collection and genotyping of Russian athletes and controls). H.Z. and E.M. were recipients of Grant-in-Aid for JSPS Fellow from the Japan Society for the Promotion of Science.
Publisher Copyright:
© 2018 Termedia Sp. z o.o. All rights reserved.
PY - 2018
Y1 - 2018
N2 - We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the AGTR2 rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, P=0.008, heterogeneity index I2=0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, P=0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, P=0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (P=0.850). The AC genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, P=0.022), but not in Japanese women athletes (P=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the AGTR2 rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.
AB - We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the AGTR2 rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, P=0.008, heterogeneity index I2=0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, P=0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, P=0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (P=0.850). The AC genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, P=0.022), but not in Japanese women athletes (P=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the AGTR2 rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.
KW - AGTR2
KW - Physical performance
KW - Power
KW - Renin-angiotensin system
KW - Sprint
KW - Track and field
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U2 - 10.5114/biolsport.2018.71599
DO - 10.5114/biolsport.2018.71599
M3 - Article
AN - SCOPUS:85045335298
SN - 0860-021X
VL - 35
SP - 105
EP - 109
JO - Biology of Sport
JF - Biology of Sport
IS - 2
ER -