AGTR2 and sprint/power performance: A case-control replication study for rs11091046 polymorphism in two ethnicities

Thomas P. Yvert, Hirofumi Zempo, Leysan J. Gabdrakhmanova, Naoki Kikuchi, Eri Miyamoto-Mikami, Haruka Murakami, Hisashi Naito, Pawel Cieszczyk, Katarzyna Leznicka, Elena S. Kostryukova, Dmitry G. Alexeev, Emiliya S. Egorova, Agnieszka Maciejewska-Skrendo, Andrey K. Larin, Edward V. Generozov, Nickolay A. Kulemin, Elena A. Ospanova, Alexander V. Pavlenko, Marek Sawczuk, Piotr ZmijewskiEwelina Lulinska-Kuklik, Vadim M. Govorun, Motohiko Miyachi, Ildus I. Ahmetov, Noriyuki Fuku*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

11 Citations (Scopus)


We aimed to replicate, in a specific athletic event cohort (only track and field) and in two different ethnicities (Japanese and East European, i.e. Russian and Polish), original findings showing the association of the angiotensin-II receptor type-2 gene (AGTR2) rs11091046 A>C polymorphism with athlete status. We compared genotypic frequencies of the AGTR2 rs11091046 polymorphism among 282 track and field sprint/power athletes (200 men and 82 women), including several national record holders and Olympic medallists (214 Japanese, 68 Russian and Polish), and 2024 control subjects (842 men and 1182 women) (804 Japanese, 1220 Russian and Polish). In men, a meta-analysis from the two combined cohorts showed a significantly higher frequency of the C allele in athletes than in controls (odds ratio: 1.62, P=0.008, heterogeneity index I2=0%). With regard to respective cohorts, C allele frequency was higher in Japanese male athletes than in controls (67.7% vs. 55.9%, P=0.022), but not in Russian/Polish male athletes (61.9% vs. 51.0%, P=0.172). In women, no significant results were obtained by meta-analysis for the two cohorts combination (P=0.850). The AC genotype frequency was significantly higher in Russian/Polish women athletes than in controls (69.2% vs. 42.1%, P=0.022), but not in Japanese women athletes (P=0.226). Our results, in contrast to previous findings, suggested by meta-analysis that the C allele of the AGTR2 rs11091046 polymorphism is associated with sprint/power track and field athlete status in men, but not in women.

Original languageEnglish
Pages (from-to)105-109
Number of pages5
JournalBiology of Sport
Issue number2
Publication statusPublished - 2018
Externally publishedYes


  • AGTR2
  • Physical performance
  • Power
  • Renin-angiotensin system
  • Sprint
  • Track and field

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation
  • Physiology (medical)


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