TY - CHAP
T1 - Algebraic and geometric understanding of cells
T2 - Epigenetic inheritance of phenotypes between generations
AU - Yasuda, Kenji
N1 - Funding Information:
The author acknowledges the assistance of all members of Yasuda Lab. Financial support, in part from the Japan Science and Technology Agency (JST) and from Grants-in-Aids for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology of the Japanese government, is gratefully appreciated.
PY - 2011
Y1 - 2011
N2 - We have developed methods and systems for analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. Because cells are minimum units reflecting epigenetic information, which is considered to map the history of a parallel-processing recurrent network of biochemical reactions, their behaviors cannot be explained by considering only conventional DNA informationprocessing events. The role of epigenetic information in cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behavior observed under conditions chosen to reveal adaptation processes and community effects. A system for analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). The knowledge acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.
AB - We have developed methods and systems for analyzing epigenetic information in cells, as well as that of genetic information, to expand our understanding of how living systems are determined. Because cells are minimum units reflecting epigenetic information, which is considered to map the history of a parallel-processing recurrent network of biochemical reactions, their behaviors cannot be explained by considering only conventional DNA informationprocessing events. The role of epigenetic information in cells, which complements their genetic information, was inferred by comparing predictions from genetic information with cell behavior observed under conditions chosen to reveal adaptation processes and community effects. A system for analyzing epigenetic information was developed starting from the twin complementary viewpoints of cell regulation as an 'algebraic' system (emphasis on temporal aspects) and as a 'geometric' system (emphasis on spatial aspects). The knowledge acquired from this study may lead to the use of cells that fully control practical applications like cell-based drug screening and the regeneration of organs.
KW - Algebraic viewpoint
KW - Epigenetic information
KW - Geometric viewpoint
KW - Individuality
KW - On-chip single-cell-based cultivation/analysis
UR - http://www.scopus.com/inward/record.url?scp=82055172637&partnerID=8YFLogxK
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U2 - 10.1007/10_2010_97
DO - 10.1007/10_2010_97
M3 - Chapter
C2 - 21072694
AN - SCOPUS:82055172637
SN - 9783642168864
T3 - Advances in Biochemical Engineering/Biotechnology
SP - 55
EP - 81
BT - High Resolution Microbial Single Cell Analytics
ER -