Alkylation of pyridine-3,5-dicarboxamide and pyridine-3,5-dicarbonitriles by radical substitution

Nobuhiro Kanomata, Hisashi Nagahara, Masaru Tada*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Structural modification of NAD(P) model compounds, N,N,N′,N′ tetramethylpyridine-3,5-dicarboxamide (1), pyridine-3,5-dicarbonitrile (2), and 4-methylpyridine-3,5-dicarbonitrile (3), have been explored by the reaction with alkyl radicals such as the 1-adamantyl, tert-butyi, and isopropyl radicals. The alkyl substitutions of compounds 1, 2, and 3 with the 1-adamantyl and the fert-butyl radical gave both 2-mono and 2,6-disubsti-tution products, whereas the reaction of compound 2 with the isopropyl radical gave 2-mono 6c, 2,4-di 7c, 2,6-di 8c, and 2,4,6-trisubstitution 9c products.

Original languageEnglish
Pages (from-to)1567-1571
Number of pages5
JournalMathematical Problems in Engineering
Issue number6
Publication statusPublished - 1992 Oct 1

ASJC Scopus subject areas

  • Mathematics(all)
  • Engineering(all)


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