Alkylation of pyridine‐3,5‐dicarboxamide and pyridine‐3,5‐dicarbonitriles by radical substitution

Nobuhiro Kanomata*, Hisashi Nagahara, Masaru Tada

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Structural modification of NAD(P) model compounds, N,N,N',N'‐tetramethylpyridine‐3,5‐dicarboxamide (1), pyridine‐3,5‐dicarbonitrile (2), and 4‐methylpyridine‐3,5‐dicarbonitrile (3), have been explored by the reaction with alkyl radicals such as the 1‐adamantyl, tert‐butyl, and isopropyl radicals. The alkyl substitutions of compounds 1, 2, and 3 with the 1‐adamantyl and the tert‐butyl radical gave both 2‐mono and 2,6‐disubstitution products, whereas the reaction of compound 2 with the isopropyl radical gave 2‐mono 6c, 2,4‐di 7c, 2,6‐di 8c, and 2,4,6‐trisubstitution 9c products.

Original languageEnglish
Pages (from-to)1567-1571
Number of pages5
JournalJournal of Heterocyclic Chemistry
Issue number6
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Organic Chemistry


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