@article{6b3ab0edf6af47d68e7c4909eb29cfa2,
title = "Alzheimer{\textquoteright}s disease mouse as a model of testis degeneration",
abstract = "Pituitary adenylate cyclase activating polypeptide (PACAP) is a neuropeptide with protective functions in the central nervous system and various peripheral organs. PACAP has the highest expression level in the testes, among the peripheral organs, and has a positive regulative role in spermatogenesis and in sperm motility. In the present study, we explored testicular degenerative alterations in a mouse model of Alzheimer{\textquoteright}s disease (AD) (B6C3-Tg(APPswe,PSEN1dE9)85Dbo/J) and demonstrated changes in PACAP-regulated signaling pathways. In addition, the effects of increased physical activity of AD (trained AD (TAD)) mice on testis were also followed. Reduced cell number and decreased thickness of basement membrane were detected in AD samples. These changes were compensated by physical activity. Expression of PACAP receptors and canonical signaling elements such as PKA, P-PKA, PP2A significantly decreased in AD mice, and altered Sox transcription factor expression was also detected. Via this signaling mechanism, physical activity compensated the negative effects of AD on the expression of type IV collagen. Our findings suggest that the testes of AD mice can be a good model of testis degeneration. Moreover, it can be an appropriate organ to follow the effects of various interventions such as physical activity on tissue regeneration and signaling alterations.",
keywords = "Alzheimer{\textquoteright}s disease, Collagen type IV, Physical activity, Sox9, Testis degeneration",
author = "Vince Szegeczki and Gabriella Horv{\'a}th and Helga Per{\'e}nyi and Andrea Tam{\'a}s and Zsolt Rad{\'a}k and D{\'o}ra {\'A}brah{\'a}m and R{\'o}za Z{\'a}k{\'a}ny and Dora Reglodi and Tam{\'a}s Juh{\'a}sz",
note = "Funding Information: Acknowledgments: The authors are grateful for Krisztina B{\'i}r{\'o} for excellent technical assistance. NKFIK115874, PD109644, K119759, NKFIHFK129190,PTE AOK Research Grant 2017-17, MTA-TKI 14016, GINOP-2.3.2-15-2016-00050 “PEPSYS”, New National Excellence Program of the Ministry of Human Capacities (UNKP-16-4-IV.), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P{\'e}cs, EFOP-3.6.2-16-2017-00008, “The role of neuro-inflammation in neurodegeneration: from molecules to clinics” Centre for Neuroscience of the University of P{\'e}cs, EFOP-3.6.3-VEKOP-16-2017-00009, University of Debrecen (OTKA Bridging Fund), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P{\'e}cs (Budapest, Hungary) NAP B KTIA NAP 13-2014-0022 (MTA-PTE NAP B Pain Research Group, identification number: 888819), NAP 2017-1.2.1-NKP-2017-00002 and OTKA-NN 114458 PTE AOK Research Grant 2017-17. The project is co-financed by the European Union and the European Social Fund. Bolyai Janos Research Scholarship (A.T.). Szodoray Lajos and Magyary Zolt{\'a}n Funds by Hungarian Academy of Science and the European Union and the State of Hungary, co-financed by the European Social Funding. Fund in the framework of T{\'A}MOP 4.2.4 (J.T.). Sz.V. is supported by the {\'U}NKP-19-3 “National Excellence Program” of the Ministry of Human Capacities. A/2-11-1-2012-0001 “National Excellence Program”. Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the FIKP II (2019) of the University of P{\'e}cs and Z.R. by National Excellence Program (126823) of Innovation and Technology Ministry, Hungary. Funding Information: The authors are grateful for Krisztina B?r? for excellent technical assistance. NKFIK115874, PD109644, K119759, NKFIHFK129190,PTE AOK Research Grant 2017-17, MTA-TKI 14016, GINOP-2.3.2-15-2016-00050 ?PEPSYS?, New National Excellence Program of the Ministry of Human Capacities (UNKP-16-4-IV.), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P?cs, EFOP-3.6.2-16-2017-00008, ?The role of neuro-inflammation in neurodegeneration: from molecules to clinics? Centre for Neuroscience of the University of P?cs, EFOP-3.6.3-VEKOP-16-2017-00009, University of Debrecen (OTKA Bridging Fund), EFOP-3.6.1.-16-2016-00004 Comprehensive Development for Implementing Smart Specialization Strategies at the University of P?cs (Budapest, Hungary) NAP B KTIA NAP 13-2014-0022 (MTA-PTE NAP B Pain Research Group, identification number: 888819), NAP 2017-1.2.1-NKP-2017-00002 and OTKA-NN 114458 PTE AOK Research Grant 2017-17. The project is co-financed by the European Union and the European Social Fund. Bolyai Janos Research Scholarship (A.T.). Szodoray Lajos and Magyary Zolt?n Funds by Hungarian Academy of Science and the European Union and the State of Hungary, co-financed by the European Social Funding. Fund in the framework of T?MOP 4.2.4 (J.T.). Sz.V. is supported by the ?NKP-19-3 ?National Excellence Program? of the Ministry of Human Capacities. A/2-11-1-2012-0001 ?National Excellence Program?. Higher Education Institutional Excellence Program of the Ministry of Human Capacities in Hungary, within the framework of the FIKP II (2019) of the University of P?cs and Z.R. by National Excellence Program (126823) of Innovation and Technology Ministry, Hungary. Publisher Copyright: {\textcopyright} 2020 by the authors. Licensee MDPI, Basel, Switzerland.",
year = "2020",
month = aug,
day = "2",
doi = "10.3390/ijms21165726",
language = "English",
volume = "21",
pages = "1--16",
journal = "International journal of molecular sciences",
issn = "1661-6596",
publisher = "Multidisciplinary Digital Publishing Institute (MDPI)",
number = "16",
}