Ambient-Light-Promoted Three-Component Annulation: Synthesis of Perfluoroalkylated Pyrimidines

Rui Wang, Wei Guan, Zheng Bo Han, Fushun Liang*, Takeo Suga, Xihe Bi, Hiroyuki Nishide

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


An ambient-light-promoted and metal-free three-component reaction of active methylene compounds, perfluoroalkyl iodides, and guanidines/amidines is reported. This constitutes a powerful method to prepare perfluoroalkylated pyrimidines with mild reaction conditions, broad substrate scope, excellent functional group tolerance, and simple operation. A radical/polar mechanism involving the formation of a halogen-bond adduct and radical cross-coupling is proposed.

Original languageEnglish
Pages (from-to)2358-2361
Number of pages4
JournalOrganic Letters
Issue number9
Publication statusPublished - 2017 May 5

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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