Animal models of anxiety and anxiolytic drug action

Dallas Treit*, Elif Engin, Kris McEown

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

43 Citations (Scopus)


Animal models of anxiety attempt to represent some aspect of the etiology, symptomatology, or treatment of human anxiety disorders, in order to facilitate their scientific study. Within this context, animal models of anxiolytic drug action can be viewed as treatment models relevant to the pharmacological control of human anxiety. A major purpose of these models is to identify novel anxiolytic compounds and to study the mechanisms whereby these compounds produce their anxiolytic effects. After a critical analysis of "face," "construct," and "predictive" validity, the biological context in which animal models of anxiety are to be evaluated is specified. We then review the models in terms of their general pharmacological profiles, with particular attention to their sensitivity to 5-HT1A agonists and antidepressant compounds. Although there are important exceptions, most of these models are sensitive to one or perhaps two classes of anxiolytic compounds, limiting their pharmacological generality somewhat, but allowing in depth analysis of individual mechanisms of anxiolytic drug action (e.g., GABAA agonism). We end with a discussion of possible sources of variability between models in response to 5-HT1A agonists and antidepressant drugs.

Original languageEnglish
Title of host publicationBehavioral Neurobiology of Anxiety and Its Treatment
PublisherSpringer Verlag
Number of pages40
ISBN (Print)9783642029110
Publication statusPublished - 2010 Jan 1
Externally publishedYes

Publication series

NameCurrent Topics in Behavioral Neurosciences
ISSN (Print)1866-3370
ISSN (Electronic)1866-3389


  • Animal models
  • Antidepressant
  • Anxiety
  • Anxiolytic
  • Biological validity
  • Construct validity
  • Drug receptors
  • Face validity

ASJC Scopus subject areas

  • Behavioral Neuroscience


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