Anti-aging effects of caloric restriction: Involvement of neuroendocrine adaptation by peripheral signaling

Takuya Chiba*, Haruyoshi Yamaza, Yoshikazu Higami, Isao Shimokawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

49 Citations (Scopus)


Many hormonal signals from peripheral tissues contribute to the regulation of energy homeostasis and food intake. These regulators including leptin, insulin, and ghrelin, modulate the orexigenic and anorexigenic neuropeptide expression in hypothalamic nuclei. The anti-aging effects of caloric restriction have been explained from an evolutional viewpoint of the adaptive response of the neuroendocrine and metabolic response systems to maximize survival during periods of food shortage. In organisms, excess energy is stored in adipose tissues as a triglyceride preparation for such survival situations. Adipose tissue has recently been recognized as an endocrine organ, and leptin, as secreted by adipocyte, seems to be an especially important factor for the adaptive response to fasting and neuroendocrine alterations under caloric restriction. In this review, we discuss the potential involvement of neuroendocrine modulators in longevity and the anti-aging effects of caloric restriction.

Original languageEnglish
Pages (from-to)317-324
Number of pages8
JournalMicroscopy Research and Technique
Issue number4
Publication statusPublished - 2002 Nov 15
Externally publishedYes


  • Adipocytokine
  • Ghrelin
  • IGF-I
  • Insulin
  • Leptin

ASJC Scopus subject areas

  • Anatomy
  • Histology
  • Instrumentation
  • Medical Laboratory Technology


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