Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin

Atsushi Honma, Tomoyuki Koyama*, Kazunaga Yazawa

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

43 Citations (Scopus)


The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di-O-galloyl-1,5-anhydro-d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.

Original languageEnglish
Pages (from-to)390-394
Number of pages5
JournalFood Chemistry
Issue number2
Publication statusPublished - 2010 Nov 15
Externally publishedYes


  • α-Glucosidase inhibitory effect
  • 2,6-di-O-galloyl-1,5-anhydro-d-glucitol
  • Acer saccharum
  • Acertannin
  • Diabetes mellitus

ASJC Scopus subject areas

  • Food Science
  • Analytical Chemistry


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