Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin

Atsushi Honma; Tomoyuki Koyama; Kazunaga Yazawa

doi:10.1016/j.foodchem.2010.04.052

Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin

Atsushi Honma, Tomoyuki Koyama^*, Kazunaga Yazawa

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

42 Citations (Scopus)

Abstract

The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di-O-galloyl-1,5-anhydro-d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.

Original language	English
Pages (from-to)	390-394
Number of pages	5
Journal	Food Chemistry
Volume	123
Issue number	2
DOIs	https://doi.org/10.1016/j.foodchem.2010.04.052
Publication status	Published - 2010 Nov 15
Externally published	Yes

Keywords

α-Glucosidase inhibitory effect
2,6-di-O-galloyl-1,5-anhydro-d-glucitol
Acer saccharum
Acertannin
Diabetes mellitus

ASJC Scopus subject areas

Food Science
Analytical Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.foodchem.2010.04.052

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title = "Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin",

abstract = "The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di-O-galloyl-1,5-anhydro-d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.",

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AU - Honma, Atsushi

AU - Koyama, Tomoyuki

AU - Yazawa, Kazunaga

PY - 2010/11/15

Y1 - 2010/11/15

N2 - The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di-O-galloyl-1,5-anhydro-d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.

AB - The anti-hyperglycemic effects of the leaves of sugar maple, Acer saccharum and purification and identification of the active compound were investigated. Extracts of the leaves showed a potent inhibitory effect on α-glucosidase in both in vivo and in vitro experiments. In vitro enzyme-inhibitory assay-guided fractionation of the crude extract gave active compound, acertannin (2,6-di-O-galloyl-1,5-anhydro-d-glucitol) by spectroscopic analysis. This is the first report that acertannin from A. saccharum may be used in diabetes care.

KW - α-Glucosidase inhibitory effect

KW - 2,6-di-O-galloyl-1,5-anhydro-d-glucitol

KW - Acer saccharum

KW - Acertannin

KW - Diabetes mellitus

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Anti-hyperglycemic effects of sugar maple Acer saccharum and its constituent acertannin

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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