Abstract
The methanolic extract of seeds of the tropical fruit camu-camu was screened for its anti-inflammatory activity in carrageenan-induced paw edema model mice. The extract significantly suppressed both the formation of edema in mice by oral administration and the release of nitric oxide from macrophage-derived RAW 264.7 cells in vitro. Based on the results of a spectroscopic analysis, the active compound was identified by in vivo bioassay-guided fractionation to be 3β -hydroxy-lup-20(29)-en-28-oic acid, betulinic acid, known as an anti-inflammatory triterpenoid. These findings suggest that camu-camu seed extract is a potentially useful material as a source of betulinic acid and as a functional food for prevention of immune-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 104-107 |
| Number of pages | 4 |
| Journal | Journal of Nutritional Science and Vitaminology |
| Volume | 57 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2011 |
| Externally published | Yes |
Keywords
- Anti-inflammatory effects in mice
- Betulinic acid
- Seed of camu-camu fruit myrciaria dubia
- Suppressive effect on nitric oxide release
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics