Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection

Fumihiko Kitagawa; Takafumi Suzuki; Hidetoshi Shinohara; Jun Mizuno; Shuichi Shoji; Koji Otsuka

Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection

Fumihiko Kitagawa, Takafumi Suzuki, Hidetoshi Shinohara, Jun Mizuno, Shuichi Shoji, Koji Otsuka

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

This paper reports a fabrication of cycloolefin polymer (COP) chip directly integrated with an electrospray ionization (ESI) emitter tip for a microchip electrophoretic (MCE) separation and mass spectrometric (MS) detection on the basis of the hot embossing, low temperature direct bonding, micromachining techniques and direct metallization onto the COP surface. By applying the fabricated COP chip to the MCE-ESI-MS analysis, a successful separation and detection of caffeine and amino acids was attained without any mechanical pump, nebulizing gas and sheath liquid.

Original language	English
Title of host publication	Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Editors	Jean-Louis Viovy, Patrick Tabeling, Stephanie Descroix, Laurent Malaquin
Publisher	Chemical and Biological Microsystems Society
Pages	1405-1407
Number of pages	3
ISBN (Electronic)	9780979806407
Publication status	Published - 2007
Event	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 - Paris, France Duration: 2007 Oct 7 → 2007 Oct 11

Publication series

Name	Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

Conference

Conference	11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007
Country/Territory	France
City	Paris
Period	07/10/7 → 07/10/11

Keywords

Cycloolefin polymer
Electrospray ionization
Mass spectrometry
Microchip electrophoresis

ASJC Scopus subject areas

Chemical Engineering (miscellaneous)
Bioengineering

Cite this

Kitagawa, F., Suzuki, T., Shinohara, H., Mizuno, J., Shoji, S., & Otsuka, K. (2007). Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection. In J-L. Viovy, P. Tabeling, S. Descroix, & L. Malaquin (Eds.), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007 (pp. 1405-1407). (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007). Chemical and Biological Microsystems Society.

Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection. / Kitagawa, Fumihiko; Suzuki, Takafumi; Shinohara, Hidetoshi et al.
Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. ed. / Jean-Louis Viovy; Patrick Tabeling; Stephanie Descroix; Laurent Malaquin. Chemical and Biological Microsystems Society, 2007. p. 1405-1407 (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Kitagawa, F, Suzuki, T, Shinohara, H, Mizuno, J, Shoji, S & Otsuka, K 2007, Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection. in J-L Viovy, P Tabeling, S Descroix & L Malaquin (eds), Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, Chemical and Biological Microsystems Society, pp. 1405-1407, 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007, Paris, France, 07/10/7.

Kitagawa F, Suzuki T, Shinohara H, Mizuno J, Shoji S, Otsuka K. Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection. In Viovy J-L, Tabeling P, Descroix S, Malaquin L, editors, Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. Chemical and Biological Microsystems Society. 2007. p. 1405-1407. (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

Kitagawa, Fumihiko ; Suzuki, Takafumi ; Shinohara, Hidetoshi et al. / Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection. Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007. editor / Jean-Louis Viovy ; Patrick Tabeling ; Stephanie Descroix ; Laurent Malaquin. Chemical and Biological Microsystems Society, 2007. pp. 1405-1407 (Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007).

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abstract = "This paper reports a fabrication of cycloolefin polymer (COP) chip directly integrated with an electrospray ionization (ESI) emitter tip for a microchip electrophoretic (MCE) separation and mass spectrometric (MS) detection on the basis of the hot embossing, low temperature direct bonding, micromachining techniques and direct metallization onto the COP surface. By applying the fabricated COP chip to the MCE-ESI-MS analysis, a successful separation and detection of caffeine and amino acids was attained without any mechanical pump, nebulizing gas and sheath liquid.",

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AU - Kitagawa, Fumihiko

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AU - Mizuno, Jun

AU - Shoji, Shuichi

AU - Otsuka, Koji

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AB - This paper reports a fabrication of cycloolefin polymer (COP) chip directly integrated with an electrospray ionization (ESI) emitter tip for a microchip electrophoretic (MCE) separation and mass spectrometric (MS) detection on the basis of the hot embossing, low temperature direct bonding, micromachining techniques and direct metallization onto the COP surface. By applying the fabricated COP chip to the MCE-ESI-MS analysis, a successful separation and detection of caffeine and amino acids was attained without any mechanical pump, nebulizing gas and sheath liquid.

KW - Cycloolefin polymer

KW - Electrospray ionization

KW - Mass spectrometry

KW - Microchip electrophoresis

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BT - Proceedings of the 11th International Conference on Miniaturized Systems for Chemistry and Life Sciences, uTAS 2007

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A2 - Malaquin, Laurent

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Application of cycloolefin polymer chip directly integrated with an electronanospray tip to electrophoretic separation and mass spectrometric detection

Abstract

Publication series

Conference

Keywords

ASJC Scopus subject areas

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