Application of hydroxyapatite-sol as drug carrier

Seisuke Kano, Atsushi Yamazaki, Ryohei Otsuka, Masataka Ohgaki, Masaru Akao, Hideki Aoki

Research output: Contribution to journalArticlepeer-review

46 Citations (Scopus)


The application of hydroxyapatite-sol as a drug carrier is being developed. Hydroxyapatite-sol which is a suspension consisting of hydroxyapatite nano-crystals, was synthesized using an ultrasonic homogenizer. The size of the crystals was 40 × 15 × 10 nm3 on average and their specific surface area was 100 m2/g. An amount of a glycoside antibiotics adsorbed onto hydroxyapatite nano-crystals was measured. The drug adsorbed 0.2 mg per 1 mg of hydroxyapatite. The affect of the drug adsorbed onto the hydroxyapatite was investigated using cancer cells. The drug, adsorbed onto the hydroxyapatite nano-crystals, inhibited cancer cell growth.

Original languageEnglish
Pages (from-to)283-290
Number of pages8
JournalBio-Medical Materials and Engineering
Issue number4
Publication statusPublished - 1994


  • Drug carrier
  • Hydroxyapatite-sol
  • Nano-crystals

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering


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