TY - JOUR
T1 - Application of infrared attenuated total reflection spectroscopy to in situ analysis of atheromatous plaques in aorta
AU - Nakamura, Atsushi
AU - Koga, Takehiro
AU - Fujimaki, Makoto
AU - Ohki, Yoshimichi
AU - Sota, Takayuki
AU - Lipinska-Kalita, Kristina
AU - Nagae, Tsuneyuki
AU - Ishimaru, Shin
AU - Aizawa, Katsuo
PY - 2000
Y1 - 2000
N2 - Ex vivo infrared attenuated total reflection (ATR) spectroscopic studies have been carried out to observe the accumulation of cholesterol ester in atheromatous plaques. It has been found that ATR spectra can be successfully obtained from the intima side of aorta and give the same information as the transmission spectra. This means, the ATR spectra include information about the chemical composition of atheromatous plaques together with the degree of eventual lesions. We have demonstrated that ATR microspectroscopic measurements can give images of atheromatous plaques distribution and enable in situ observation of the relative amount of accumulated cholesterol ester. The results clearly indicate that the ATR spectroscopy enables spectroscopic diagnoses in vivo as well as in vitro.
AB - Ex vivo infrared attenuated total reflection (ATR) spectroscopic studies have been carried out to observe the accumulation of cholesterol ester in atheromatous plaques. It has been found that ATR spectra can be successfully obtained from the intima side of aorta and give the same information as the transmission spectra. This means, the ATR spectra include information about the chemical composition of atheromatous plaques together with the degree of eventual lesions. We have demonstrated that ATR microspectroscopic measurements can give images of atheromatous plaques distribution and enable in situ observation of the relative amount of accumulated cholesterol ester. The results clearly indicate that the ATR spectroscopy enables spectroscopic diagnoses in vivo as well as in vitro.
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U2 - 10.1143/jjap.39.l490
DO - 10.1143/jjap.39.l490
M3 - Article
AN - SCOPUS:0033689216
SN - 0021-4922
VL - 39
SP - L490-L492
JO - Japanese Journal of Applied Physics, Part 2: Letters
JF - Japanese Journal of Applied Physics, Part 2: Letters
IS - 6 A
ER -