Assessment of the effects of a wireless neural stimulation mediated by piezoelectric nanoparticles

Attilio Marino, Satoshi Arai, Yanyan Hou, Mario Pellegrino, Barbara Mazzolai, Virgilio Mattoli, Madoka Suzuki, Gianni Ciofani*

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Wireless neuronal stimulation, mediated by ultrasounds and piezoelectric nanoparticles, represents an unprecedented approach aimed at cell activation. Recently, we demonstrated that barium titanate nanoparticles behave as excellent nanotransducers, by eliciting specific cell response following treatment with ultrasounds. In this chapter, we describe in detail the techniques exploited to investigate the nanoparticle/cell interactions and the activation of the neuronal-like cultures in terms of sodium and calcium fluxes.

Original languageEnglish
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Number of pages12
Publication statusPublished - 2018 Jan 1
Externally publishedYes

Publication series

ISSN (Print)0893-2336
ISSN (Electronic)1940-6045


  • Barium titanate nanoparticles
  • Calcium imaging
  • Piezoelectricity
  • SH-SY5Y cells
  • Sodium imaging
  • Ultrasounds

ASJC Scopus subject areas

  • General Neuroscience
  • General Biochemistry,Genetics and Molecular Biology
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health


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