TY - JOUR
T1 - Association between ACTN3 R577X Polymorphism and Trunk Flexibility in 2 Different Cohorts
AU - Kikuchi, Naoki
AU - Zempo, Hirofumi
AU - Fuku, Noriyuki
AU - Murakami, Haruka
AU - Sakamaki-Sunaga, Mikako
AU - Okamoto, Takanobu
AU - Nakazato, Koichi
AU - Miyachi, Motohiko
N1 - Funding Information:
This study was funded by a Grant-in-Aid for Young Scientists (B) (B15K16467 to N.K.), Grant-in-Aid for Scientific Research (B) (15H03081 to N.F.), and Grant-in-Aid for Scientific Research (C) (23500788 to K.N.) from the Ministry of Education, Culture, Sports, Science and Technology, and by a Grant-in Aid for Scientific Research from the Ministry of Health, Labor, and Welfare of Japan (to M.M.). H.Z. is a recipient of a Grant-in-Aid for JSPS Post-Doctoral Fellows from the Japan Society for the Promotion of Science NK and HZ contributed equally to this work. KN and MM shared senior authorship.
Publisher Copyright:
© Georg Thieme Verlag KG Stuttgart.New York.
PY - 2017/5/1
Y1 - 2017/5/1
N2 - α-Actinin-3 (ACTN3) R577X polymorphism is associated with muscular strength and power. This study was performed to investigate the association between ACTN3 R577X polymorphisms and flexibility as another component of fitness in 2 cohorts. Cohort 1 consisted of 208 men and 568 women (ages 23-88), while Cohort 2 consisted of 529 men and 728 women (ages 23-87). All participants were recruited from the Tokyo metropolitan area and underwent a battery of tests to assess their grip strength and sit-and-reach flexibility. Genotyping results were analyzed for ACTN3 (rs1815739) polymorphism using the TaqMan approach. In Cohort 1, sit-and-reach in the RR genotype (35.3±0.7 cm) was significantly lower than those in the RX and XX genotypes (37.2±0.3 cm) even after adjusting for sex, age, and exercise habit as covariates (P<0.01). In Cohort 2, sit-and-reach tended to be lower in RR (38.1±0.6 cm) than in RX and XX (39.1±0.3 cm), but the differences were not significant (P=0.114). Analysis in pooled subjects indicated that RR was associated with significantly lower flexibility than RX and XX (P=0.009). The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.
AB - α-Actinin-3 (ACTN3) R577X polymorphism is associated with muscular strength and power. This study was performed to investigate the association between ACTN3 R577X polymorphisms and flexibility as another component of fitness in 2 cohorts. Cohort 1 consisted of 208 men and 568 women (ages 23-88), while Cohort 2 consisted of 529 men and 728 women (ages 23-87). All participants were recruited from the Tokyo metropolitan area and underwent a battery of tests to assess their grip strength and sit-and-reach flexibility. Genotyping results were analyzed for ACTN3 (rs1815739) polymorphism using the TaqMan approach. In Cohort 1, sit-and-reach in the RR genotype (35.3±0.7 cm) was significantly lower than those in the RX and XX genotypes (37.2±0.3 cm) even after adjusting for sex, age, and exercise habit as covariates (P<0.01). In Cohort 2, sit-and-reach tended to be lower in RR (38.1±0.6 cm) than in RX and XX (39.1±0.3 cm), but the differences were not significant (P=0.114). Analysis in pooled subjects indicated that RR was associated with significantly lower flexibility than RX and XX (P=0.009). The RR genotype of ACTN3 R577X in the general Japanese population showed lower flexibility compared to the RX and XX genotypes.
KW - genotype
KW - meta-analysis
KW - sit-and-reach
KW - α-actinin 3
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U2 - 10.1055/s-0042-118649
DO - 10.1055/s-0042-118649
M3 - Article
C2 - 28303562
AN - SCOPUS:85015609121
SN - 0172-4622
VL - 38
SP - 402
EP - 406
JO - International Journal of Sports Medicine
JF - International Journal of Sports Medicine
IS - 5
ER -