TY - JOUR
T1 - Association Between Personal Activity Intelligence and Mortality
T2 - Population-Based China Kadoorie Biobank Study
AU - Nauman, Javaid
AU - Franklin, Barry A.
AU - Nes, Bjarne M.
AU - Sallis, Robert E.
AU - Sawada, Susumu S.
AU - Marinović, Jasna
AU - Stensvold, Dorthe
AU - Lavie, Carl J.
AU - Tari, Atefe R.
AU - Wisløff, Ulrik
N1 - Funding Information:
The China Kadoorie Biobank study is jointly coordinated by the University of Oxford and Chinese Academy of Medical Sciences. The authors thank the participants in the study and the members of the survey teams, as well as the project development and management teams based at Beijing, China, and Oxford, UK. The authors also thank Professor Canqing Yu from the Department of Epidemiology and Biostatistics, School of Public Health, Peking University Health Science Center, Beijing, People's Republic of China, for help in CKB data acquisition and providing responses to our queries about the data. Grant Support: This work was supported by grants from the Norwegian Research Council and the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and technology. The funding organizations had no role in the design and execution of the study, in the collection, analyses or interpretation of the data. Further, they had no role in the preparation, review or approval of the manuscript.
Funding Information:
Grant Support: This work was supported by grants from the Norwegian Research Council and the Liaison Committee between the Central Norway Regional Health Authority and the Norwegian University of Science and technology. The funding organizations had no role in the design and execution of the study, in the collection, analyses or interpretation of the data. Further, they had no role in the preparation, review or approval of the manuscript.
Publisher Copyright:
© 2021 The Authors
PY - 2022/4
Y1 - 2022/4
N2 - Objective: To prospectively investigate the association between personal activity intelligence (PAI) — a novel metabolic metric which translates heart rate during physical activity into a simple weekly score — and mortality in relatively healthy participants in China whose levels and patterns of physical activity in addition to other lifestyle factors are different from those in high-income countries. Patients and Methods: From the population-based China Kadoorie Biobank study, 443,792 healthy adults were recruited between June 2004 and July 2008. Participant's weekly PAI score was estimated and divided into four groups (PAI scores of 0, ≤50, 51–99, or ≥100). Using Cox proportional hazard analyses, we calculated adjusted hazard ratios (AHRs) for cardiovascular disease (CVD) and all-cause mortality related to PAI scores. Results: During a median follow-up of 8.2 (interquartile range, 7.3 to 9.1) years, there were 21,901 deaths, including 9466 CVD deaths. Compared with the inactive group (0 PAI score), a baseline weekly PAI score greater than or equal to 100 was associated with a lower risk of CVD mortality, an AHR of 0.87 (95% CI, 0.81 to 0.94) in men, and an AHR of 0.84 (95% CI, 0.78 to 0.92) in women, after adjusting for multiple confounders. Participants with a weekly PAI score greater than or equal to 100 also had a lower risk of all-cause mortality (AHR, 0.93; 95% CI, 0.89 to 0.97 in men, and AHR, 0.93; 95%, 0.88 to 0.98 in women). Moreover, this subgroup gained 2.7 (95% CI, 2.4 to 3.0) years of life, compared with the inactive cohort. Conclusion: Among relatively healthy Chinese adults, the PAI metric was inversely associated with CVD and all-cause mortality, highlighting the generalizability of the score in different races, ethnicities, and socioeconomic strata.
AB - Objective: To prospectively investigate the association between personal activity intelligence (PAI) — a novel metabolic metric which translates heart rate during physical activity into a simple weekly score — and mortality in relatively healthy participants in China whose levels and patterns of physical activity in addition to other lifestyle factors are different from those in high-income countries. Patients and Methods: From the population-based China Kadoorie Biobank study, 443,792 healthy adults were recruited between June 2004 and July 2008. Participant's weekly PAI score was estimated and divided into four groups (PAI scores of 0, ≤50, 51–99, or ≥100). Using Cox proportional hazard analyses, we calculated adjusted hazard ratios (AHRs) for cardiovascular disease (CVD) and all-cause mortality related to PAI scores. Results: During a median follow-up of 8.2 (interquartile range, 7.3 to 9.1) years, there were 21,901 deaths, including 9466 CVD deaths. Compared with the inactive group (0 PAI score), a baseline weekly PAI score greater than or equal to 100 was associated with a lower risk of CVD mortality, an AHR of 0.87 (95% CI, 0.81 to 0.94) in men, and an AHR of 0.84 (95% CI, 0.78 to 0.92) in women, after adjusting for multiple confounders. Participants with a weekly PAI score greater than or equal to 100 also had a lower risk of all-cause mortality (AHR, 0.93; 95% CI, 0.89 to 0.97 in men, and AHR, 0.93; 95%, 0.88 to 0.98 in women). Moreover, this subgroup gained 2.7 (95% CI, 2.4 to 3.0) years of life, compared with the inactive cohort. Conclusion: Among relatively healthy Chinese adults, the PAI metric was inversely associated with CVD and all-cause mortality, highlighting the generalizability of the score in different races, ethnicities, and socioeconomic strata.
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U2 - 10.1016/j.mayocp.2021.10.022
DO - 10.1016/j.mayocp.2021.10.022
M3 - Article
C2 - 34865822
AN - SCOPUS:85120870164
SN - 0025-6196
VL - 97
SP - 668
EP - 681
JO - Mayo Clinic Proceedings
JF - Mayo Clinic Proceedings
IS - 4
ER -