Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex

Shuhei Murayama; Yoichi Nakao; Shigeki Matsunaga

doi:10.1016/j.tetlet.2008.04.043

Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex

Shuhei Murayama, Yoichi Nakao, Shigeki Matsunaga^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

A new pteridine derivative, asteropterin (1), was isolated as a cathepsin B inhibitor from the marine sponge Asteropus simplex. The structure of asteropterin (1) was elucidated by the analysis of spectral data.

Original language	English
Pages (from-to)	4186-4188
Number of pages	3
Journal	Tetrahedron Letters
Volume	49
Issue number	26
DOIs	https://doi.org/10.1016/j.tetlet.2008.04.043
Publication status	Published - 2008 Jun 23
Externally published	Yes

Keywords

Cathepsin B
Inhibitor
Lumazine
Sponge

ASJC Scopus subject areas

Biochemistry
Drug Discovery
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.tetlet.2008.04.043

Cite this

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title = "Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex",

abstract = "A new pteridine derivative, asteropterin (1), was isolated as a cathepsin B inhibitor from the marine sponge Asteropus simplex. The structure of asteropterin (1) was elucidated by the analysis of spectral data.",

keywords = "Cathepsin B, Inhibitor, Lumazine, Sponge",

author = "Shuhei Murayama and Yoichi Nakao and Shigeki Matsunaga",

note = "Funding Information: We thank Dr. Kazuo Furihata of the University of Tokyo for his assistance in measuring NMR spectra. We also acknowledge Professor Rob W. M. van Soest, Zoological Museum of University of Amsterdam for the identification of the sponge (ZMAPOR 16718). This work was partly supported by Grant-in-Aid for Scientific Research on Priority Areas 16073207 from MEXT.",

year = "2008",

month = jun,

day = "23",

doi = "10.1016/j.tetlet.2008.04.043",

language = "English",

volume = "49",

pages = "4186--4188",

journal = "Tetrahedron Letters",

issn = "0040-4039",

publisher = "Elsevier Limited",

number = "26",

}

TY - JOUR

T1 - Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex

AU - Murayama, Shuhei

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

N1 - Funding Information: We thank Dr. Kazuo Furihata of the University of Tokyo for his assistance in measuring NMR spectra. We also acknowledge Professor Rob W. M. van Soest, Zoological Museum of University of Amsterdam for the identification of the sponge (ZMAPOR 16718). This work was partly supported by Grant-in-Aid for Scientific Research on Priority Areas 16073207 from MEXT.

PY - 2008/6/23

Y1 - 2008/6/23

N2 - A new pteridine derivative, asteropterin (1), was isolated as a cathepsin B inhibitor from the marine sponge Asteropus simplex. The structure of asteropterin (1) was elucidated by the analysis of spectral data.

AB - A new pteridine derivative, asteropterin (1), was isolated as a cathepsin B inhibitor from the marine sponge Asteropus simplex. The structure of asteropterin (1) was elucidated by the analysis of spectral data.

KW - Cathepsin B

KW - Inhibitor

KW - Lumazine

KW - Sponge

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U2 - 10.1016/j.tetlet.2008.04.043

DO - 10.1016/j.tetlet.2008.04.043

M3 - Article

AN - SCOPUS:43849092308

SN - 0040-4039

VL - 49

SP - 4186

EP - 4188

JO - Tetrahedron Letters

JF - Tetrahedron Letters

IS - 26

ER -

Asteropterin, an inhibitor of cathepsin B, from the marine sponge Asteropus simplex

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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