TY - JOUR
T1 - Asymmetric synthesis of optically active fluorine-containing alcohols by the catalytic enantioselective alkylation of aldehydes
AU - Hayase, Tadakatsu
AU - Sugiyama, Tadashi
AU - Suzuki, Masanori
AU - Shibata, Takanori
AU - Soai, Kenso
N1 - Funding Information:
This work was financially supported by a Grant-in-Aid from the Ministry of Education, Science, Sports and Culture.
PY - 1997/8/31
Y1 - 1997/8/31
N2 - Optically active fluorine-containing alcohols with up to 97% enantiomeric excess were synthesized by the enantioselective addition of dialkylzincs to fluorine-containing aldehydes using chiral β-aminoalcohol catalysts such as N,N-dibutylnorephedrine (DBNE, 2d), 2-morpholino-1-phenyl-1-propanol (2g, MOPEP) and diphenyl(1-methylpyrrolidin-2-yl)methanol (3, DPMPM).
AB - Optically active fluorine-containing alcohols with up to 97% enantiomeric excess were synthesized by the enantioselective addition of dialkylzincs to fluorine-containing aldehydes using chiral β-aminoalcohol catalysts such as N,N-dibutylnorephedrine (DBNE, 2d), 2-morpholino-1-phenyl-1-propanol (2g, MOPEP) and diphenyl(1-methylpyrrolidin-2-yl)methanol (3, DPMPM).
KW - Aldehydes
KW - Asymmetric synthesis
KW - Catalytic enantioselective alkylation
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U2 - 10.1016/S0022-1139(97)00039-0
DO - 10.1016/S0022-1139(97)00039-0
M3 - Article
AN - SCOPUS:0031592774
SN - 0022-1139
VL - 84
SP - 1
EP - 5
JO - Journal of Fluorine Chemistry
JF - Journal of Fluorine Chemistry
IS - 1
ER -