TY - JOUR
T1 - Asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products
AU - Hosokawa, Seijiro
AU - Tatsuta, Kuniaki
PY - 2008/2
Y1 - 2008/2
N2 - Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
AB - Asymmetric vinylogous aldol reaction is a powerful methodology to introduce a multi functional group in the stereoselective manner. Recently, we have developed highly stereoselective vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals possessing the chiral oxazolidone. Our methodology has been applied to the asymmetric syntheses of natural products to establish the short and efficient routes. This review focuses on the asymmetric vinylogous Mukaiyama aldol reactions using vinylketene N,O-acetals in total syntheses of natural products.
KW - Natural product
KW - Polyketide
KW - Remote stereoinduction
KW - Total synthesis
KW - Vinylketene N,O-acetal
KW - Vinylogous Mukaiyama aldol reaction
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U2 - 10.2174/157019308783498197
DO - 10.2174/157019308783498197
M3 - Review article
AN - SCOPUS:39749091198
SN - 1570-193X
VL - 5
SP - 1
EP - 18
JO - Mini-Reviews in Organic Chemistry
JF - Mini-Reviews in Organic Chemistry
IS - 1
ER -