TY - JOUR
T1 - Attenuation of the contingency detection effect in the extrastriate body area in autism spectrum disorder
AU - Okamoto, Yuko
AU - Kitada, Ryo
AU - Tanabe, Hiroki C.
AU - Hayashi, Masamichi J.
AU - Kochiyama, Takanori
AU - Munesue, Toshio
AU - Ishitobi, Makoto
AU - Saito, Daisuke N.
AU - Yanaka, Hisakazu T.
AU - Omori, Masao
AU - Wada, Yuji
AU - Okazawa, Hidehiko
AU - Sasaki, Akihiro T.
AU - Morita, Tomoyo
AU - Itakura, Shoji
AU - Kosaka, Hirotaka
AU - Sadato, Norihiro
N1 - Funding Information:
This work was partly supported by Grants-in-Aid for Scientific Research from the Japan Society for the Promotion of Science to N. Sadato ( 21220005 ), T. Munesue ( 21591509 ), H. Kosaka ( 21791120 ) and R. Kitada ( 25871059 ). Part of this study was the result of the project “Development of biomarker candidates for social behavior” and “Integrated research on neuropsychiatric disorders” carried out under the Strategic Research Program for Brain Sciences by the Ministry of Education, Culture, Sports, Science, and Technology of Japan (MEXT). H. Kosaka was also supported by the Takeda Science Foundation , the Japan Research Foundation for Clinical Pharmacology , and the SENSHIN Medical Research Foundation . M.J. Hayashi was supported by Brain Research at Aalto University and University of Helsinki consortium postdoctoral program.
Publisher Copyright:
© 2014 Elsevier Ireland Ltd and the Japan Neuroscience Society.
PY - 2014
Y1 - 2014
N2 - Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of autism spectrum disorder (ASD). To depict the neural underpinnings of this contingency effect, 19 adults with ASD and 22 control participants underwent functional MRI while imitating another's actions and their actions being imitated by the other. As the extrastriate body area (EBA) receives efference copies of one's own movements, we predicted that the EBA would show an atypical response during contingency detection in ASD. We manipulated two factors: the congruency of the executed and observed actions, and the order of action execution and observation. Both groups showed the congruency effect in the bilateral EBA during imitation. When action preceded observation, the left EBA of the control group showed the congruency effect, representing the response to being imitated, indicating contingency detection. The ASD group showed a reduced contingency effect in the left EBA. These results indicate that the function of the EBA in the contingency detection is altered in ASD.
AB - Detection of the contingency between one's own behavior and consequent social events is important for normal social development, and impaired contingency detection may be a cause of autism spectrum disorder (ASD). To depict the neural underpinnings of this contingency effect, 19 adults with ASD and 22 control participants underwent functional MRI while imitating another's actions and their actions being imitated by the other. As the extrastriate body area (EBA) receives efference copies of one's own movements, we predicted that the EBA would show an atypical response during contingency detection in ASD. We manipulated two factors: the congruency of the executed and observed actions, and the order of action execution and observation. Both groups showed the congruency effect in the bilateral EBA during imitation. When action preceded observation, the left EBA of the control group showed the congruency effect, representing the response to being imitated, indicating contingency detection. The ASD group showed a reduced contingency effect in the left EBA. These results indicate that the function of the EBA in the contingency detection is altered in ASD.
KW - Autism spectrum disorders
KW - Being imitated
KW - Extrastriate body area
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U2 - 10.1016/j.neures.2014.06.012
DO - 10.1016/j.neures.2014.06.012
M3 - Article
C2 - 25066523
AN - SCOPUS:84927573862
SN - 0168-0102
VL - 87
SP - 66
EP - 76
JO - Neuroscience Research
JF - Neuroscience Research
IS - C
ER -