Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Yasumoto Oyadomari; Yasuyuki Goto; Keisuke Suganuma; Shin Ichiro Kawazu; Leontine E. Becking; Nobuhiro Fusetani; Yoichi Nakao

doi:10.3390/md22040171

Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Yasumoto Oyadomari, Yasuyuki Goto, Keisuke Suganuma, Shin Ichiro Kawazu, Leontine E. Becking, Nobuhiro Fusetani, Yoichi Nakao^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

Abstract

A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC₅₀ value of 0.74 µM.

Original language	English
Article number	171
Journal	Marine Drugs
Volume	22
Issue number	4
DOIs	https://doi.org/10.3390/md22040171
Publication status	Published - 2024 Apr

Keywords

Siliquariaspongia japonica
anti-leishmanial activity
aurantosides
marine natural products
marine sponge
mass spectrometry
nuclear magnetic resonance

ASJC Scopus subject areas

Pharmaceutical Science
Drug Discovery
Pharmacology, Toxicology and Pharmaceutics (miscellaneous)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.3390/md22040171

Cite this

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title = "Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica",

abstract = "A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.",

keywords = "Siliquariaspongia japonica, anti-leishmanial activity, aurantosides, marine natural products, marine sponge, mass spectrometry, nuclear magnetic resonance",

author = "Yasumoto Oyadomari and Yasuyuki Goto and Keisuke Suganuma and Kawazu, {Shin Ichiro} and Becking, {Leontine E.} and Nobuhiro Fusetani and Yoichi Nakao",

note = "Publisher Copyright: {\textcopyright} 2024 by the authors.",

year = "2024",

month = apr,

doi = "10.3390/md22040171",

language = "English",

volume = "22",

journal = "Marine Drugs",

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T1 - Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

AU - Oyadomari, Yasumoto

AU - Goto, Yasuyuki

AU - Suganuma, Keisuke

AU - Kawazu, Shin Ichiro

AU - Becking, Leontine E.

AU - Fusetani, Nobuhiro

AU - Nakao, Yoichi

PY - 2024/4

Y1 - 2024/4

N2 - A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

AB - A new tetramic acid glycoside, aurantoside L (1), was isolated from the sponge Siliquariaspongia japonica collected at Tsushima Is., Nagasaki Prefecture, Japan. The structure of aurantoside L (1) composed of a tetramic acid bearing a chlorinated polyene system and a trisaccharide part was elucidated using spectral analysis. Aurantoside L (1) showed anti-parasitic activity against L. amazonensis with an IC50 value of 0.74 µM.

KW - Siliquariaspongia japonica

KW - anti-leishmanial activity

KW - aurantosides

KW - marine natural products

KW - marine sponge

KW - mass spectrometry

KW - nuclear magnetic resonance

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DO - 10.3390/md22040171

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Aurantoside L, a New Tetramic Acid Glycoside with Anti-Leishmanial Activity Isolated from the Marine Sponge Siliquariaspongia japonica

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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