TY - JOUR
T1 - Axinelloside A, an unprecedented highly sulfated lipopolysaccharide inhibiting telomerase, from the marine sponge, Axinella infundibula
AU - Warabi, Kaoru
AU - Hamada, Toshiyuki
AU - Nakao, Yoichi
AU - Matsunaga, Shigeki
AU - Hirota, Hiroshi
AU - Van Soest, Rob W.M.
AU - Fusetani, Nobuhiro
PY - 2005/9/28
Y1 - 2005/9/28
N2 - Axinelloside A was isolated from the lipophilic extract of the Japanease marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC50 2.0 μg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.
AB - Axinelloside A was isolated from the lipophilic extract of the Japanease marine sponge Axinella infundibula as a strong human telomerase inhibitor (IC50 2.0 μg/mL). It has the molecular weight of 4780.4 as the monoisotopic mass of the 19 sodium salt. The chemical structure was elucidated mainly by spectroscopic methods (2D NMR and MS). Axinelloside A consists of twelve sugars, e.g., a scyllo-inositol, a D-arabinose, 5 D-galactoses, and 5 L-fucoses, together with an (R)-3-hydroxy-octadecanoic acid, 3 (E)-2-hexadecenoic acids, and 19 sulfates.
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U2 - 10.1021/ja052688r
DO - 10.1021/ja052688r
M3 - Article
C2 - 16173756
AN - SCOPUS:25444504553
SN - 0002-7863
VL - 127
SP - 13262
EP - 13270
JO - Journal of the American Chemical Society
JF - Journal of the American Chemical Society
IS - 38
ER -
