Benign adult familial myoclonus epilepsy with depressive state: A case report

Masaki Nishida*, Masaaki Kato, Sunao Uchida, Teiichi Onuma

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Benign adult familial myoclonus epilepsy (BAFME) is a rare epileptic disease that has predominantly been reported in the Japanese population. To date, there have been no reports of psychotic symptoms in BAFME patients. We recently encountered one patient with BAFME accompanied by an apparently related major depressive episode. The depressive state did not improve after trials of several antidepressive agents, including clomipramine, fluvoxamine and alprazolam. However, clonazapam was very effective and immediately improved both the affective disorder and epileptic symptoms. Electroencephalographic (EEG) findings also improved, reflected by normalization of background activity and spikey waves. This clinical course could indicate that the depressive state derived from epileptic pathophysiology.

Original languageEnglish
Pages (from-to)37-40
Number of pages4
JournalNeurology Psychiatry and Brain Research
Issue number1
Publication statusPublished - 2001 Dec 1
Externally publishedYes


  • Action myoclonus
  • Clonazepam
  • Depressive symtoms

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology
  • Psychiatry and Mental health


Dive into the research topics of 'Benign adult familial myoclonus epilepsy with depressive state: A case report'. Together they form a unique fingerprint.

Cite this