Bilberry anthocyanins ameliorate NAFLD by improving dyslipidemia and gut microbiome dysbiosis

Hironobu Nakano, Shusong Wu, Kozue Sakao, Taichi Hara, Jianhua He, Santos Garcia, Kalidas Shetty, De Xing Hou*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

38 Citations (Scopus)


Non-alcoholic fatty liver disease (NAFLD) is a manifestation of metabolic syndrome closely linked to dyslipidemia and gut microbiome dysbiosis. Bilberry anthocyanins (BA) have been reported to have preventive effects against metabolic syndrome. This study aimed to investigate the protective effects and mechanisms of BA in aWestern diet (WD)-induced mouse model. The results revealed that supplementation with BA attenuated the serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), low-density lipoprotein cholesterol (LDL-c), fat content in liver, 2-thiobarbituric acid reactive substances (TBARS) and α-smooth muscle actin (α-SMA) caused by WD. Furthermore, gut microbiota characterized by 16S rRNA sequencing revealed that BA reduced remarkably the ratio of Firmicutes/Bacteroidetes (F/B) and modified gut microbiome. In particular, BA increased the relative abundance of g_Akkermansia and g_Parabacteroides. Taken together, our data demonstrated that BA might ameliorate WD-induced NAFLD by attenuating dyslipidemia and gut microbiome dysbiosis.

Original languageEnglish
Article number3252
Pages (from-to)1-16
Number of pages16
Issue number11
Publication statusPublished - 2020 Nov


  • Anthocyanins
  • Bilberry
  • Dyslipidemia
  • Gut microbiome

ASJC Scopus subject areas

  • Food Science
  • Nutrition and Dietetics


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