Biochemical analysis of the bone of SHC rats with spontaneous hypercholesterolemia and renal dysfunction

K. Sudo*, K. Shiota, T. Masaki, R. Tsukuda, T. Fujita

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Spontaneously hypercholesterolemic (SHC) rats exhibit severe abnormalities in renal function and bone metabolism at old ages, in addition to hypercholesterolemia. SHC rats were also found to show endocrine abnormalities such as hyperthyroidism from young ages. In this study, biochemical and microdensitometric analyses were carried out using femurs to characterize further the abnormality in bone metabolism: whether biochemical markers of the bone may be affected by these abnormalities. At 6 weeks of age, the ashed weight and calcium content of the dried femurs were slightly lower in SHC rats than in age-matched Sprague-Dawley (SD) rats. None of the markers of microdensitometric analysis was changed. At 24 weeks of age, the ashed weight of dried femurs and the density of the marrow region of femurs were lower in the SHC rats. The results indicate that SHC rats exhibit severe abnormality in bone metabolism leading to biochemical changes in the bone at old ages whereas changes in bone markers were minimal at young ages before the onset of severe renal dysfunction.

Original languageEnglish
Pages (from-to)147-151
Number of pages5
JournalEndocrinologia Japonica
Issue number1
Publication statusPublished - 1992
Externally publishedYes


  • Bone
  • Renal dysfunction
  • Spontaneously hypercholesterolemic (SHC) rats

ASJC Scopus subject areas

  • Endocrinology


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