Bioengineering applications of ultra-thin poly(lactic acid) nanofilms towards cellbased smart biomaterials

Leonardo Ricotti*, Toshinori Fujie, Virginia Pensabene, Arianna Menciassi

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)


Poly(lactic acid) (PLA) ultra-thin films (nanofilms) came up in the last years as novel materials for therapeutic and surgical applications, as well as conceptually new tools in the fields of tissue engineering and regenerative medicine. The present chapter describes the preparation methods to obtain PLA structures with a nanometric thickness and a large surface area, reporting the main features of such devices and the possibilities of functionalizing them by means of the inclusion in the polymeric matrix of nanoparticles with targeted physical properties. In vitro evidences regarding the interactions of mammalian cells with PLA nanofilms are described, based on studies carried out with fibroblasts, skeletal and cardiac muscle cells, osteoblasts, and rat and human mesenchymal stem cells. The application of PLA ultra-thin films for in vitro tissue regeneration and in vivo applications are also described, highlighting the novel contribution that such structures could bring in comparison with traditional biomaterials and bioengineering approaches.

Original languageEnglish
Title of host publicationPolylactic Acid: Synthesis, Properties and Applications
PublisherNova Science Publishers, Inc.
Number of pages15
ISBN (Print)9781621003489
Publication statusPublished - 2012 Jan

ASJC Scopus subject areas

  • Chemistry(all)


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