Bioengineering of bacterial magnetic particles and their applications in biotechnology

Tomoko Yoshino, Yoshiaki Maeda, Tadashi Matsunaga*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Magnetic particles have attracted much attention for their versatile uses in biotechnology, especially in medical applications. The major advantage of magnetic particles is that they can be easily manipulated by magnetic forces. Mag-netotactic bacteria synthesize nano-sized biomagnetites, otherwise known as bacterial magnetic particles (BacMPs) that are individually enveloped by a lipid bilayer membrane. The mechanisms of BacMP synthesis have been analyzed by ge-nomic, proteomic, and bioinformatic approaches. Based on those studies in Magnetospirillum magneticum AMB-1, functional nanomaterials have been designed and produced. Through genetic engineering, functional proteins such as enzymes, antibodies, and receptors have been successfully displayed on BacMPs. These functional BacMPs have been utilized in various biosensors and bio-separation processes. Here, recent papers and patents for bioengineering of BacMPs and their applications in biotechnology are reviewed. The elucidation of the mechanism of magnetic particle synthesis has provided a roadmap for the design of novel biomaterials that can play useful roles in multiple disciplinary fields.

Original languageEnglish
Pages (from-to)214-225
Number of pages12
JournalRecent Patents on Biotechnology
Issue number3
Publication statusPublished - 2010
Externally publishedYes


  • Anchor
  • Automated system
  • Bacteria
  • Bio-separation
  • Biosensors
  • Display
  • Gene fusion
  • Magnetic particles
  • Protein engineering

ASJC Scopus subject areas

  • Biotechnology
  • Applied Microbiology and Biotechnology
  • Bioengineering


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