Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Antonios P. Antoniadis; Peter Mortier; Ghassan Kassab; Gabriele Dubini; Nicolas Foin; Yoshinobu Murasato; Andreas A. Giannopoulos; Shengxian Tu; Kiyotaka Iwasaki; Yutaka Hikichi; Francesco Migliavacca; Claudio Chiastra; Jolanda J. Wentzel; Frank Gijsen; Johan H.C. Reiber; Peter Barlis; Patrick W. Serruys; Deepak L. Bhatt; Goran Stankovic; Elazer R. Edelman; George D. Giannoglou; Yves Louvard; Yiannis S. Chatzizisis

doi:10.1016/j.jcin.2015.06.015

Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Antonios P. Antoniadis, Peter Mortier, Ghassan Kassab, Gabriele Dubini, Nicolas Foin, Yoshinobu Murasato, Andreas A. Giannopoulos, Shengxian Tu, Kiyotaka Iwasaki, Yutaka Hikichi, Francesco Migliavacca, Claudio Chiastra, Jolanda J. Wentzel, Frank Gijsen, Johan H.C. Reiber, Peter Barlis, Patrick W. Serruys, Deepak L. Bhatt, Goran Stankovic, Elazer R. EdelmanGeorge D. Giannoglou, Yves Louvard, Yiannis S. Chatzizisis^*

^*Corresponding author for this work

Graduate School of Advanced Science and Engineering

Research output: Contribution to journal › Review article › peer-review

78 Citations (Scopus)

Abstract

Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

Original language	English
Article number	2103
Pages (from-to)	1281-1296
Number of pages	16
Journal	JACC: Cardiovascular Interventions
Volume	8
Issue number	10
DOIs	https://doi.org/10.1016/j.jcin.2015.06.015
Publication status	Published - 2015 Aug 24

Keywords

bifurcation
biomechanical stress
coronary artery disease
endothelial shear stress
stent(s)

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1016/j.jcin.2015.06.015

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Antoniadis, A. P., Mortier, P., Kassab, G., Dubini, G., Foin, N., Murasato, Y., Giannopoulos, A. A., Tu, S., Iwasaki, K., Hikichi, Y., Migliavacca, F., Chiastra, C., Wentzel, J. J., Gijsen, F., Reiber, J. H. C., Barlis, P., Serruys, P. W., Bhatt, D. L., Stankovic, G., ... Chatzizisis, Y. S. (2015). Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation. JACC: Cardiovascular Interventions, 8(10), 1281-1296. [2103]. https://doi.org/10.1016/j.jcin.2015.06.015

Antoniadis, AP, Mortier, P, Kassab, G, Dubini, G, Foin, N, Murasato, Y, Giannopoulos, AA, Tu, S, Iwasaki, K, Hikichi, Y, Migliavacca, F, Chiastra, C, Wentzel, JJ, Gijsen, F, Reiber, JHC, Barlis, P, Serruys, PW, Bhatt, DL, Stankovic, G, Edelman, ER, Giannoglou, GD, Louvard, Y & Chatzizisis, YS 2015, 'Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation', JACC: Cardiovascular Interventions, vol. 8, no. 10, 2103, pp. 1281-1296. https://doi.org/10.1016/j.jcin.2015.06.015

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title = "Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation",

abstract = "Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.",

keywords = "bifurcation, biomechanical stress, coronary artery disease, endothelial shear stress, stent(s)",

author = "Antoniadis, {Antonios P.} and Peter Mortier and Ghassan Kassab and Gabriele Dubini and Nicolas Foin and Yoshinobu Murasato and Giannopoulos, {Andreas A.} and Shengxian Tu and Kiyotaka Iwasaki and Yutaka Hikichi and Francesco Migliavacca and Claudio Chiastra and Wentzel, {Jolanda J.} and Frank Gijsen and Reiber, {Johan H.C.} and Peter Barlis and Serruys, {Patrick W.} and Bhatt, {Deepak L.} and Goran Stankovic and Edelman, {Elazer R.} and Giannoglou, {George D.} and Yves Louvard and Chatzizisis, {Yiannis S.}",

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year = "2015",

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day = "24",

doi = "10.1016/j.jcin.2015.06.015",

language = "English",

volume = "8",

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T2 - Expert Review Document on Techniques and Clinical Implementation

AU - Antoniadis, Antonios P.

AU - Mortier, Peter

AU - Kassab, Ghassan

AU - Dubini, Gabriele

AU - Foin, Nicolas

AU - Murasato, Yoshinobu

AU - Giannopoulos, Andreas A.

AU - Tu, Shengxian

AU - Iwasaki, Kiyotaka

AU - Hikichi, Yutaka

AU - Migliavacca, Francesco

AU - Chiastra, Claudio

AU - Wentzel, Jolanda J.

AU - Gijsen, Frank

AU - Reiber, Johan H.C.

AU - Barlis, Peter

AU - Serruys, Patrick W.

AU - Bhatt, Deepak L.

AU - Stankovic, Goran

AU - Edelman, Elazer R.

AU - Giannoglou, George D.

AU - Louvard, Yves

AU - Chatzizisis, Yiannis S.

PY - 2015/8/24

Y1 - 2015/8/24

N2 - Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

AB - Treatment of coronary bifurcation lesions remains an ongoing challenge for interventional cardiologists. Stenting of coronary bifurcations carries higher risk for in-stent restenosis, stent thrombosis, and recurrent clinical events. This review summarizes the current evidence regarding application and use of biomechanical modeling in the study of stent properties, local flow dynamics, and outcomes after percutaneous coronary interventions in bifurcation lesions. Biomechanical modeling of bifurcation stenting involves computational simulations and in vitro bench testing using subject-specific arterial geometries obtained from in vivo imaging. Biomechanical modeling has the potential to optimize stenting strategies and stent design, thereby reducing adverse outcomes. Large-scale clinical studies are needed to establish the translation of pre-clinical findings to the clinical arena.

KW - bifurcation

KW - biomechanical stress

KW - coronary artery disease

KW - endothelial shear stress

KW - stent(s)

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Biomechanical Modeling to Improve Coronary Artery Bifurcation Stenting: Expert Review Document on Techniques and Clinical Implementation

Abstract

Keywords

ASJC Scopus subject areas

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