TY - JOUR
T1 - Body mass-to-waist ratio strongly correlates with skeletal muscle volume in children
AU - Ohta, Megumi
AU - Midorikawa, Taishi
AU - Hikihara, Yuki
AU - Sakamoto, Shizuo
AU - Kawakami, Yasuo
AU - Fukunaga, Tetsuo
AU - Kanehisa, Hiroaki
N1 - Publisher Copyright:
© 2017 Ohta et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PY - 2017/5
Y1 - 2017/5
N2 - Purpose We hypothesized that body mass-to-waist ratio is strongly associated with the total-body skeletal muscle volume (SMV) in children. The purpose of the present study was to examine this hypothesis. Methods By using magnetic resonance imaging, total-body SMV (SMVMRI) was determined in 70 boys and 53 girls aged 6 to 12 years. Waist was measured at each of the level of umbilicus (Wumb) and the minimum circumference (Wmin), and the ratio of body mass to each of the two measured values was calculated (BM/Wumb and BM/Wmin, respectively). A single regression analysis was used to examine the relationships between SMVMRI and either BM/Wumb or BM/Wmin. On the basis of the obtained regression equations, SMVMRI was estimated and referred to as SMVBM/Wumb or SMVBM/Wmin. Results In both boys and girls, SMVMRI was highly correlated to BM/Wumb (r = 0.937 for boys and r = 0.939 for girls, P < 0.0001) and BM/Wmin (r = 0.915 and 0.942, P < 0.0001). R2 and the standard error of estimate for SMVBM/Wumb were 0.878 and 706.2 cm3, respectively, in boys and 0.882 and 825.3 cm3, respectively, in girls, and those for SMVBM/Wmin were 0.837 and 814.0 cm3, respectively, in boys and 0.888 and 804.1 cm3, respectively, in girls. In both boys and girls, there were no significant differences between SMVMRI and either SMVBM/Wumb or SMVBM/Wmin, without systematic errors in Band-Altman plots. There was no significant effect of model on the absolute values of the residuals in both boys and girls. Conclusion The current results indicate that body mass-to-waist ratio can be a convenient outcome measure for assessing the total-body skeletal muscle volume in children.
AB - Purpose We hypothesized that body mass-to-waist ratio is strongly associated with the total-body skeletal muscle volume (SMV) in children. The purpose of the present study was to examine this hypothesis. Methods By using magnetic resonance imaging, total-body SMV (SMVMRI) was determined in 70 boys and 53 girls aged 6 to 12 years. Waist was measured at each of the level of umbilicus (Wumb) and the minimum circumference (Wmin), and the ratio of body mass to each of the two measured values was calculated (BM/Wumb and BM/Wmin, respectively). A single regression analysis was used to examine the relationships between SMVMRI and either BM/Wumb or BM/Wmin. On the basis of the obtained regression equations, SMVMRI was estimated and referred to as SMVBM/Wumb or SMVBM/Wmin. Results In both boys and girls, SMVMRI was highly correlated to BM/Wumb (r = 0.937 for boys and r = 0.939 for girls, P < 0.0001) and BM/Wmin (r = 0.915 and 0.942, P < 0.0001). R2 and the standard error of estimate for SMVBM/Wumb were 0.878 and 706.2 cm3, respectively, in boys and 0.882 and 825.3 cm3, respectively, in girls, and those for SMVBM/Wmin were 0.837 and 814.0 cm3, respectively, in boys and 0.888 and 804.1 cm3, respectively, in girls. In both boys and girls, there were no significant differences between SMVMRI and either SMVBM/Wumb or SMVBM/Wmin, without systematic errors in Band-Altman plots. There was no significant effect of model on the absolute values of the residuals in both boys and girls. Conclusion The current results indicate that body mass-to-waist ratio can be a convenient outcome measure for assessing the total-body skeletal muscle volume in children.
UR - http://www.scopus.com/inward/record.url?scp=85019131083&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85019131083&partnerID=8YFLogxK
U2 - 10.1371/journal.pone.0177155
DO - 10.1371/journal.pone.0177155
M3 - Article
C2 - 28475638
AN - SCOPUS:85019131083
SN - 1932-6203
VL - 12
JO - PloS one
JF - PloS one
IS - 5
M1 - e0177155
ER -