Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou; T. Li; Masahisa Nakada; Conrad W. Hummel; A. Hiatt; W. Wrasidlo

doi:10.1002/anie.199401831

Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

K. C. Nicolaou^*, T. Li, Masahisa Nakada, Conrad W. Hummel, A. Hiatt, W. Wrasidlo

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

60 Citations (Scopus)

Abstract

The attack of a thiolate ion on the trisulfide unit of natural calicheamicin γ I1 (1) activates it to form a diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH^‐ ions—and likewise exhibits extremely interesting biological properties. (Figure Presented.)

Original language	English
Pages (from-to)	183-186
Number of pages	4
Journal	Angewandte Chemie International Edition in English
Volume	33
Issue number	2
DOIs	https://doi.org/10.1002/anie.199401831
Publication status	Published - 1994 Feb 1
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)

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abstract = "The attack of a thiolate ion on the trisulfide unit of natural calicheamicin γ I1 (1) activates it to form a diradical, which then attacks DNA. Thioacetate 2 is even more readily activated—under mildly basic conditions caused by OH‐ ions—and likewise exhibits extremely interesting biological properties. (Figure Presented.)",

author = "Nicolaou, {K. C.} and T. Li and Masahisa Nakada and Hummel, {Conrad W.} and A. Hiatt and W. Wrasidlo",

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AU - Wrasidlo, W.

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Calicheamicin θ 1I: A Rationally Designed Molecule with Extremely Potent and Selective DNA Cleaving Properties and Apoptosis Inducing Activity

Abstract

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