Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita; Yoichi Nakao; Shigeki Matsunaga; Rob W.M. Van Soest; Yoshifumi Itoh; Motoharu Seiki; Nobuhiro Fusetani

doi:10.1021/np020572s

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Masaki Fujita, Yoichi Nakao, Shigeki Matsunaga, Rob W.M. Van Soest, Yoshifumi Itoh, Motoharu Seiki, Nobuhiro Fusetani^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Abstract

Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC₅₀ of 15.0 μg/mL.

Original language	English
Pages (from-to)	569-571
Number of pages	3
Journal	Journal of Natural Products
Volume	66
Issue number	4
DOIs	https://doi.org/10.1021/np020572s
Publication status	Published - 2003 Apr 1
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Molecular Medicine
Pharmacology
Pharmaceutical Science
Drug Discovery
Complementary and alternative medicine
Organic Chemistry

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1021/np020572s

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abstract = "Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.",

author = "Masaki Fujita and Yoichi Nakao and Shigeki Matsunaga and {Van Soest}, {Rob W.M.} and Yoshifumi Itoh and Motoharu Seiki and Nobuhiro Fusetani",

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AU - Fujita, Masaki

AU - Nakao, Yoichi

AU - Matsunaga, Shigeki

AU - Van Soest, Rob W.M.

AU - Itoh, Yoshifumi

AU - Seiki, Motoharu

AU - Fusetani, Nobuhiro

PY - 2003/4/1

Y1 - 2003/4/1

N2 - Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

AB - Callysponginol sulfate A (1) was isolated from the marine sponge Callyspongia truncata as a membrane type 1 matrix metalloproteinase (MT1-MMP) inhibitor. Its structure was elucidated by a combination of spectroscopic and chemical methods and found to be a new sulfated C24 acetylenic fatty acid. Compound 1 inhibited MT1-MMP with an IC50 of 15.0 μg/mL.

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JO - Journal of Natural Products

JF - Journal of Natural Products

IS - 4

ER -

Callysponginol sulfate A, an MT1-MMP inhibitor isolated from the marine sponge Callyspongia truncata

Abstract

ASJC Scopus subject areas

UN SDGs

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