Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Kenward K.H. Vong; Kazuki Tsubokura; Yoichi Nakao; Tomonori Tanei; Shinzaburo Noguchi; Shinobu Kitazume; Naoyuki Taniguchi; Katsunori Tanaka

doi:10.1039/c7cc01934c

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Kenward K.H. Vong, Kazuki Tsubokura, Yoichi Nakao, Tomonori Tanei, Shinzaburo Noguchi, Shinobu Kitazume, Naoyuki Taniguchi, Katsunori Tanaka^*

^*Corresponding author for this work

School of Advanced Science and Engineering

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

Original language	English
Pages (from-to)	8403-8406
Number of pages	4
Journal	Chemical Communications
Volume	53
Issue number	60
DOIs	https://doi.org/10.1039/c7cc01934c
Publication status	Published - 2017

ASJC Scopus subject areas

Electronic, Optical and Magnetic Materials
General Chemistry
Ceramics and Composites
Metals and Alloys
Materials Chemistry
Surfaces, Coatings and Films
Catalysis

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1039/c7cc01934c

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title = "Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters",

abstract = "Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.",

author = "Vong, {Kenward K.H.} and Kazuki Tsubokura and Yoichi Nakao and Tomonori Tanei and Shinzaburo Noguchi and Shinobu Kitazume and Naoyuki Taniguchi and Katsunori Tanaka",

note = "Publisher Copyright: {\textcopyright} 2017 The Royal Society of Chemistry.",

year = "2017",

doi = "10.1039/c7cc01934c",

language = "English",

volume = "53",

pages = "8403--8406",

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TY - JOUR

T1 - Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

AU - Vong, Kenward K.H.

AU - Tsubokura, Kazuki

AU - Nakao, Yoichi

AU - Tanei, Tomonori

AU - Noguchi, Shinzaburo

AU - Kitazume, Shinobu

AU - Taniguchi, Naoyuki

AU - Tanaka, Katsunori

PY - 2017

Y1 - 2017

N2 - Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

AB - Rapidly growing cancer cells have increased levels of intracellular polyamines compared to normal, healthy tissues. Based on the selective reactivity of glycine propargyl esters, probes were synthesized that show evidence for selective polyamine reactivity, which was then applied for selective cancer cell imaging studies.

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U2 - 10.1039/c7cc01934c

DO - 10.1039/c7cc01934c

M3 - Article

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AN - SCOPUS:85026328584

SN - 1359-7345

VL - 53

SP - 8403

EP - 8406

JO - Chemical Communications

JF - Chemical Communications

IS - 60

ER -

Cancer cell targeting driven by selective polyamine reactivity with glycine propargyl esters

Abstract

ASJC Scopus subject areas

UN SDGs

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