Carbon Nanotubes-Hydroxyapatite Nanocomposites for an Improved Osteoblast Cell Response

Sabrina Constanda, Miruna Silvia Stan, Carmen Steluţa Ciobanu, Mikael Motelica-Heino, Régis Guégan, Khalid Lafdi, Anca Dinischiotu*, Daniela Predoi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

29 Citations (Scopus)


An alternative and simple coprecipitation method was developed to obtain carbon nanotube-hydroxyapatite (CNTs:HAp) based nanocomposites. The incorporation of CNTs (in a concentration of 5% and 10% of total weight of the nanocomposite) and their impact on both structural and biological properties were studied by using a set of standard complementary biological, microscopic, and spectroscopic techniques. The characteristic peaks of carbon structure in CNTs were not observed in the CNTs-HAp composites by X-ray diffraction analysis. Moreover, FTIR and Raman spectroscopies confirmed the presence of HAp as the main phase of the synthesized CNTs:HAp nanocomposites. The addition of CNTs considerably affected the nanocomposite morphology by increasing the average crystallite size from 18.7 nm (for raw HAp) to 28.6 nm (for CNTs:HAp-10), confirming their proper incorporation. The biocompatibility evaluation of CNTs:HAp-5 and CNTs:HAp-10 nanocomposites included the assessment of several parameters, such as cell viability, antioxidant response, and lipid peroxidation, on human G-292 osteoblast cell line. Our findings revealed good biocompatibility properties for CNTs:HAp nanocomposites prepared by the coprecipitation method supporting their potential uses in orthopedics and prosthetics.

Original languageEnglish
Article number3941501
JournalJournal of Nanomaterials
Publication statusPublished - 2016
Externally publishedYes

ASJC Scopus subject areas

  • General Materials Science


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