Cardiac stimulant action of constituents of Aloe saponaria

Akira Yagi*, Shoji Shibata, Itsuo Nishioka, Shuichi Iwadare, Yukisato Ishida

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


A highly potent cardiotonic substance, calcium isocitrate, was isolated from Aloe saponaria, using solvent partition, nonionic porous resin, and gel permeation chromatographies. Cardiac stimulant activity of synthesized stereoisomers of calcium isocitrate was demonstrated in isolated guinea pig atria.

Original languageEnglish
Pages (from-to)739-741
Number of pages3
JournalJournal of Pharmaceutical Sciences
Issue number7
Publication statusPublished - 1982 Jul
Externally publishedYes


  • Aloe Saponaria—cardiac stimulation activity of various constituents, calcium isocitrate
  • Stereoisomers—synthesis of calcium isocitrate stereoisomers, cardiac stimulation activity, rats, rabbits, guinea pigs
  • calcium isocitrate—isolated from Aloe saponaria, cardiac stimulation of rabbit and rat, and guinea pig atria

ASJC Scopus subject areas

  • Pharmaceutical Science


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